Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis (Q24609324)

2

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Asligul Yalcin-Chin

3

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Lin Li

4

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Michael Peyton

5

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John Minna

6

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Patrick Harran

7

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Xiaodong Wang

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

8

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language of work or name

English

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publication date

November 2007

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published in

Cancer Cell

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volume

12

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issue

5

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page(s)

445-56

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cites work

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IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

7 April 2017

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The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

7 April 2017

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X-linked IAP is a direct inhibitor of cell-death proteases

7 April 2017

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The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

7 April 2017

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TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

7 April 2017

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Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs

7 April 2017

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Structural basis of IAP recognition by Smac/DIABLO

7 April 2017

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

7 April 2017

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Structural and biochemical basis of apoptotic activation by Smac/DIABLO

7 April 2017

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

7 April 2017

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

7 April 2017

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The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

7 April 2017

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Cell death: critical control points

7 April 2017

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Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma

7 April 2017

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TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90

7 April 2017

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A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

7 April 2017

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

7 April 2017

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Signalling pathways of the TNF superfamily: a double-edged sword

7 April 2017

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NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

7 April 2017

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The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

7 April 2017

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Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic.

7 April 2017

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Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)

27 September 2017

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Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis

27 September 2017

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Synthetic Smac peptide enhances the effect of etoposide-induced apoptosis in human glioblastoma cell lines

27 September 2017

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Promoting apoptosis as a strategy for cancer drug discovery

27 September 2017

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27 September 2017

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A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

27 September 2017

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The inhibitor of apoptosis protein family (IAPs): an emerging therapeutic target in cancer

27 September 2017

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The role of Bcl-2 family members in tumorigenesis

27 September 2017

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Receptor-mediated choreography of life and death.

27 September 2017

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27 September 2017

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Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction

27 September 2017

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STI571 (Gleevec) as a paradigm for cancer therapy

27 September 2017

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27 September 2017

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RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis

27 September 2017

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An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif

27 September 2017

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Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line.

27 September 2017

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A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells

27 September 2017

1 reference

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Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.

28 November 2018

1 reference

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A high-throughput screen for identification of molecular mimics of Smac/DIABLO utilizing a fluorescence polarization assay.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431210

Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors.

28 November 2018

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Tumour biology: herceptin acts as an anti-angiogenic cocktail.

28 November 2018

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Targeting macrophages with microspheres containing cytokine-neutralizing antibodies prevents lethality in gram-negative peritonitis

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17996648

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17996648

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2007.08.029

1 reference

1901152

1901152

1 reference

1 reference

1 reference