Regulating mammalian target of rapamycin to tune vaccination-induced CD8(+) T cell responses for tumor immunity (Q24610550)

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Rajesh Rao

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Joseph Vazzana

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Peter Goedegebuure

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William Gillanders

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Protul A Shrikant

mTOR regulates memory CD8 T-cell differentiation

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language of work or name

English

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publication date

1 April 2012

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published in

Journal of Immunology

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volume

188

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issue

7

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page(s)

3080-7

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cites work

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Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation

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A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity

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The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

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The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells.

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Enhancing CD8 T-cell memory by modulating fatty acid metabolism

27 September 2017

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Fifteen years of clinical studies and clinical practice in renal transplantation: reviewing outcomes with de novo use of sirolimus in combination with cyclosporine

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Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor

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Expanding mTOR signaling

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Activation phenotype, rather than central- or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cells

27 September 2017

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Vaccination with NY-ESO-1 protein and CpG in Montanide induces integrated antibody/Th1 responses and CD8 T cells through cross-priming.

27 September 2017

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Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

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Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response

27 September 2017

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Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909.

27 September 2017

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Immunosuppressive drugs for kidney transplantation.

27 September 2017

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Route of immunization with peptide-pulsed dendritic cells controls the distribution of memory and effector T cells in lymphoid tissues and determines the pattern of regional tumor control

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Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function

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CD8(+) T cell responses against a dominant cryptic HLA-A2 epitope after NY-ESO-1 peptide immunization of cancer patients

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Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope

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Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accomp

27 September 2017

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High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy.

27 September 2017

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The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

27 September 2017

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Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

30 May 2018

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Introduction of soluble protein into the class I pathway of antigen processing and presentation

30 May 2018

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Fine-tuning CD8(+) T cell functional responses: mTOR acts as a rheostat for regulating CD8(+) T cell proliferation, survival and differentiation?

30 May 2018

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The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin

28 November 2018

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Ex vivo rapamycin generates apoptosis-resistant donor Th2 cells that persist in vivo and prevent hemopoietic stem cell graft rejection

28 November 2018

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CD8+ T cell contraction is controlled by early inflammation.

28 November 2018

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A triad of costimulatory molecules synergize to amplify T-cell activation

28 November 2018

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12 December 2020

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

1 reference

12 December 2020

Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection

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12 December 2020

Murine recipients of fully mismatched donor marrow are protected from lethal graft-versus-host disease by the in vivo administration of rapamycin but develop an autoimmune-like syndrome

1 reference

12 December 2020

Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells

1 reference

12 December 2020

Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation

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12 December 2020

A role for mammalian target of rapamycin in regulating T cell activation versus anergy

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12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1103365

1 reference

1 reference

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PubMed publication ID

22379028

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