The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. (Q34801853)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21358638%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

title

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2 (English)

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23 January 2020

4

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23 January 2020

author name string

Greg M Delgoffe

1

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23 January 2020

Kristen N Pollizzi

2

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23 January 2020

Adam T Waickman

3

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23 January 2020

David J Meyers

5

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23 January 2020

Maureen R Horton

6

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23 January 2020

Bo Xiao

7

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23 January 2020

Paul F Worley

8

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23 January 2020

Jonathan D Powell

9

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23 January 2020

language of work or name

English

0 references

publication date

27 February 2011

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23 January 2020

1 reference

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23 January 2020

volume

12

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23 January 2020

page(s)

295-303

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23 January 2020

issue

4

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Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways

23 January 2020

cites work

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The mTORC2 complex regulates terminal differentiation of C2C12 myoblasts

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8 July 2018

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

8 July 2018

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T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

8 July 2018

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Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

8 July 2018

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Nogo-66 promotes the differentiation of neural progenitors into astroglial lineage cells through mTOR-STAT3 pathway

8 July 2018

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The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

8 July 2018

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De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR.

8 July 2018

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Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells

8 July 2018

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Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity

8 July 2018

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Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance

8 July 2018

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8 July 2018

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8 July 2018

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

8 July 2018

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

8 July 2018

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Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

8 July 2018

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8 July 2018

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8 July 2018

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The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin

8 July 2018

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Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas

26 October 2018

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26 October 2018

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Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

26 October 2018

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IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis.

26 October 2018

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IL-7 enhances the survival and maintains the size of naive T cells

26 October 2018

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Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements

26 October 2018

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KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21358638

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21358638

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NI.2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21358638%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21358638%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

1 reference