Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability (Q24610709)

2

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Olga Azarenko

3

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Xiaojie Zhu

4

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Bryan M Lewis

5

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Bruce A Littlefield

6

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Mary Ann Jordan

Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase

7

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language of work or name

English

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publication date

16 February 2010

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published in

Biochemistry

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volume

49

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issue

6

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page(s)

1331-7

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cites work

1 reference

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Structural insight into the inhibition of tubulin by vinca domain peptide ligands

7 April 2017

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The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth

7 April 2017

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Microtubules as a target for anticancer drugs

7 April 2017

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In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B

7 April 2017

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Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

7 April 2017

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

7 April 2017

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How do microtubule-targeted drugs work? An overview

7 April 2017

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Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin.

27 September 2017

1 reference

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Vinorelbine neurotoxicity: clinical and neurophysiological findings in 23 patients

27 September 2017

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Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies

27 September 2017

1 reference

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Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B

27 September 2017

1 reference

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Low potency of taxol at microtubule minus ends: implications for its antimitotic and therapeutic mechanism.

27 September 2017

1 reference

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Kinetic stabilization of microtubule dynamic instability in vitro by vinblastine.

30 May 2018

1 reference

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Paclitaxel-induced neuropathy

30 May 2018

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Arrangement of subunits in flagellar microtubules.

30 May 2018

1 reference

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A monoclonal antibody against the type II isotype of beta-tubulin. Preparation of isotypically altered tubulin.

30 May 2018

1 reference

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Kinetic analysis of tubulin exchange at microtubule ends at low vinblastine concentrations.

30 May 2018

1 reference

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Mechanism of action of vinblastine. Binding of [acetyl-3H]-vinblastine to embryonic chick brain tubulin and tubulin from sea urchin sperm tail outer doublet microtubules

30 May 2018

1 reference

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Structure-activity study of the inhibition of microtubule assembly in vitro by podophyllotoxin and its congeners

30 May 2018

1 reference

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Macromolecular interaction of halichondrin B analogues eribulin (E7389) and ER-076349 with tubulin by analytical ultracentrifugation.

30 May 2018

1 reference

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A phase I study of eribulin mesylate (E7389), a mechanistically novel inhibitor of microtubule dynamics, in patients with advanced solid malignancies.

28 November 2018

1 reference

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Phase I study of eribulin mesylate administered once every 21 days in patients with advanced solid tumors.

28 November 2018

1 reference

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Phase II study of eribulin mesylate, a halichondrin B analog, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane

28 November 2018

1 reference

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Structural basis for the regulation of tubulin by vinblastine

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846717

Kinetic stabilization of microtubule dynamics at steady state by tau and microtubule-binding domains of tau.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846717

Interaction of vinblastine with steady-state microtubules in vitro.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2846717

Chemotherapy-induced peripheral neuropathy

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20030375

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Halichondrins - antitumor polyether macrolides from a marine sponge

1 reference

20 August 2023

https://opencitations.net/index/coci/api/v1/citations/10.1351/PAC198658050701

Identifiers

DOI

10.1021/BI901810U

1 reference

1937265

1937265

1 reference

1 reference

1 reference