Scaffold proteins: hubs for controlling the flow of cellular information (Q24611517)

BioNumbers--the database of key numbers in molecular and cell biology

Europe PubMed Central

title

Scaffold proteins: hubs for controlling the flow of cellular information (English)

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Jesse G Zalatan

2

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author name string

Matthew C Good

series ordinal

1

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Wendell A Lim

series ordinal

3

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language of work or name

English

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publication date

6 May 2011

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published in

Science

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volume

332

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issue

6030

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page(s)

680-6

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cites work

1 reference

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7 April 2017

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7 April 2017

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Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway

7 April 2017

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Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate Effect

7 April 2017

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The scaffold protein Ste5 directly controls a switch-like mating decision in yeast

7 April 2017

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7 April 2017

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7 April 2017

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Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

7 April 2017

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Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade.

7 April 2017

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Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions

7 April 2017

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Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex

7 April 2017

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The yersinia virulence factor YopM forms a novel protein complex with two cellular kinases

7 April 2017

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PDZ domain proteins: scaffolds for signaling complexes

7 April 2017

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Structure of carbamoyl phosphate synthetase: a journey of 96 A from substrate to product

7 April 2017

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Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

7 April 2017

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A cytoplasmic inhibitor of the JNK signal transduction pathway

7 April 2017

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KSR modulates signal propagation within the MAPK cascade

7 April 2017

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A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

7 April 2017

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Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

22 April 2017

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HSP90 at the hub of protein homeostasis: emerging mechanistic insights

22 April 2017

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Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

7 April 2017

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Single-cell analysis reveals that insulation maintains signaling specificity between two yeast MAPK pathways with common components

7 April 2017

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The C-terminal tail of Yersinia pseudotuberculosis YopM is critical for interacting with RSK1 and for virulence

27 September 2017

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Cell signaling in space and time: where proteins come together and when they're apart

27 September 2017

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27 September 2017

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Signaling dynamics of the KSR1 scaffold complex

27 September 2017

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Scaffold proteins and immune-cell signalling

27 September 2017

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Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex

27 September 2017

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27 September 2017

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27 September 2017

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Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117218

Scaffold proteins confer diverse regulatory properties to protein kinase cascades.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117218

Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117218

Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117218

Cell-signalling dynamics in time and space

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117218

The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117218

Mitogen-activated protein kinases with distinct requirements for Ste5 scaffolding influence signaling specificity in Saccharomyces cerevisiae

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117218

Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117218

Contribution of translational and rotational motions to molecular association in aqueous solution

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117218

Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117218

The molecular basis of substrate channeling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117218

Mutational analysis of STE5 in the yeast Saccharomyces cerevisiae: application of a differential interaction trap assay for examining protein-protein interactions.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117218

Quantitative effect of scaffold abundance on signal propagation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117218

Ste5 RING-H2 domain: role in Ste4-promoted oligomerization for yeast pheromone signaling

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117218

A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117218

Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5.

30 May 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1198701

Identification of the minimal tyrosine residues required for linker for activation of T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1198701

Synthetic metabolic pipelines

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1198701

A Membrane Binding Domain in the Ste5 Scaffold Synergizes with Gβγ Binding to Control Localization and Signaling in Pheromone Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1198701

The price of lost freedom: entropy of bimolecular complex formation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21551057

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1198701

1 reference

40390

ADS bibcode

2011Sci...332..680G

0 references

40390

1 reference

1 reference

1 reference