A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK (Q27667127)

2

0 references

Nicholas T Hertz

3

0 references

William C H Chao

4

0 references

Alma L Burlingame

5

0 references

Kevan M Shokat

6

0 references

David Barford

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

7

0 references

language of work or name

English

0 references

publication date

21 April 2011

0 references

published in

Nature

0 references

volume

472

0 references

issue

7343

0 references

page(s)

366-9

0 references

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

KSR, a novel protein kinase required for RAS signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

KSR and CNK: two scaffolds regulating RAS-mediated RAF activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

KSR modulates signal propagation within the MAPK cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

KSR stimulates Raf-1 activity in a kinase-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

A dimerization-dependent mechanism drives RAF catalytic activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Signaling dynamics of the KSR1 scaffold complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Kinase suppressor of Ras is ceramide-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Three-dimensional structure of the tyrosine kinase c-Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Tuning a Three-Component Reaction For Trapping Kinase Substrate Complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

KSR is a scaffold required for activation of the ERK/MAPK module

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Patterns of somatic mutation in human cancer genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

The CCP4 suite: programs for protein crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

CaspR: a web server for automated molecular replacement using homology modelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Improvement of the GenTHREADER method for genomic fold recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Production of selenomethionyl-derivatized proteins in baculovirus-infected insect cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

A semisynthetic epitope for kinase substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Quantitative analysis of synaptic phosphorylation and protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE09860

Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21441910

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

3DCoffee@igs: a web server for combining sequences and structures into a multiple sequence alignment

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21441910