Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal (Q24613178)

1

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Leigh D Plant

2

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Greta Sokoloff

3

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Andrew J Hawk

4

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Ivy Aneas

5

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Gerald E Wuenschell

6

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John Termini

7

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Stephen C Meredith

8

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Marcelo A Nobrega

9

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Abraham A Palmer

Journal of Clinical Investigation

10

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language of work or name

English

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publication date

June 2012

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published in

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volume

122

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issue

6

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page(s)

2306-15

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Reactive metabolites and AGE/RAGE-mediated cellular dysfunction affect the aging process: a mini-review

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Restless legs syndrome: pathophysiology, clinical presentation and management

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Role of GABAA receptors in the physiology and pharmacology of sleep

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Anxiety in mice and men: a comparison

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Pitfalls in the interpretation of genetic and pharmacological effects on anxiety-like behaviour in rodents

27 September 2017

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The tandem of free radicals and methylglyoxal

27 September 2017

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Animal models of anxiety in mice

27 September 2017

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Relevance of BAC transgene copy number in mice: transgene copy number variation across multiple transgenic lines and correlations with transgene integrity and expression

27 September 2017

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A genetic risk factor for periodic limb movements in sleep

27 September 2017

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27 September 2017

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Role of GABA in anxiety and depression

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27 September 2017

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Unease on the role of glyoxalase 1 in high-anxiety-related behaviour

27 September 2017

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27 September 2017

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Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice.

27 September 2017

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Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety.

27 September 2017

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Presynaptic, extrasynaptic and axonal GABAA receptors in the CNS: where and why?

27 September 2017

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Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics

27 September 2017

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Protecting the genome: defence against nucleotide glycation and emerging role of glyoxalase I overexpression in multidrug resistance in cancer chemotherapy

27 September 2017

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27 September 2017

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Molecular targets in the treatment of anxiety

27 September 2017

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Subunit composition, distribution and function of GABA(A) receptor subtypes

27 September 2017

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27 September 2017

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27 September 2017

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Recombineering: a powerful new tool for mouse functional genomics

27 September 2017

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GABAergic mechanisms in epilepsy

27 September 2017

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The glyoxalase system in health and disease

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Methylglyoxal-mediated anxiolysis involves increased protein modification and elevated expression of glyoxalase 1 in the brain

28 November 2018

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Methylglyoxal, protein binding and biological samples: are we getting the true measure?

28 November 2018

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Reduced expression of glyoxalase-1 mRNA in mood disorder patients

28 November 2018

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Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans

28 November 2018

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Methylglyoxal causes strong weakening of detoxifying capacity and apoptotic cell death in rat hippocampal neurons.

28 November 2018

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Association analysis of the functional Ala111Glu polymorphism of the glyoxalase I gene in panic disorder

28 November 2018

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Proteomic studies identified a single nucleotide polymorphism in glyoxalase I as autism susceptibility factor.

28 November 2018

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Methylglyoxal induces oxidative stress-dependent cell injury and up-regulation of interleukin-1beta and nerve growth factor in cultured hippocampal neuronal cells

28 November 2018

1 reference

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Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366407

Alterations in the expression of GABAA receptor subunits in cerebellar granule cells after the disruption of the alpha6 subunit gene.

28 November 2018

1 reference

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Inhibition of glyoxalase I by S-substituted glutathiones

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22585572

12 December 2020

inferred from PubMed ID database lookup

A simplified method for the purification of human red blood cell glyoxalase. I. Characteristics, immunoblotting, and inhibitor studies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22585572

12 December 2020

inferred from PubMed ID database lookup

Antitumor Activity ofS-(p-Bromobenzyl)glutathione Diestersin Vitro: A Structure−Activity Study

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22585572

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1172/JCI61319

1 reference

release_47gjkb6evnd4fltvhlmtcptbna

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/47gjkb6evnd4fltvhlmtcptbna

24 November 2022

mapped directly with Wikidata item

1 reference

1 reference

PubMed publication ID

22585572

1 reference