Reactive metabolites and AGE/RAGE-mediated cellular dysfunction affect the aging process: a mini-review (Q37801791)

23 August 2017

Reactive metabolites and AGE/RAGE-mediated cellular dysfunction affect the aging process: a mini-review (English)

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23 August 2017

3

Peter P Nawroth

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23 August 2017

4

Angelika Bierhaus

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23 August 2017

2

Per M Humpert

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23 August 2017

Thomas H Fleming

1

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23 August 2017

21 October 2010

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23 August 2017

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23 August 2017

57

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23 August 2017

435-443

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23 August 2017

5

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Mitochondria, oxidants, and aging

23 August 2017

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Oxidants, oxidative stress and the biology of ageing

21 January 2018

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How mitochondria produce reactive oxygen species

21 January 2018

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Oxy-radicals and related species: their formation, lifetimes, and reactions

21 January 2018

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Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

21 January 2018

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Increased dicarbonyl metabolism in endothelial cells in hyperglycemia induces anoikis and impairs angiogenesis by RGD and GFOGER motif modification

21 January 2018

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Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease

21 January 2018

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Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

21 January 2018

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Contribution of polyol pathway to diabetes-induced oxidative stress

21 January 2018

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Biochemistry and molecular cell biology of diabetic complications

21 January 2018

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On the Origin of Cancer Cells

21 January 2018

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Why do cancers have high aerobic glycolysis?

21 January 2018

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Reactive oxygen species: a double-edged sword in oncogenesis

21 January 2018

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Female fitness in Drosophila melanogaster: an interaction between the effect of nutrition and of encounter rate with males.

21 January 2018

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Extending the lifespan of long-lived mice

21 January 2018

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Effects of diet restriction on life span and age-related changes in dogs

21 January 2018

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Caloric restriction and aging in primates: Relevance to humans and possible CR mimetics

21 January 2018

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Genetic pathways that regulate ageing in model organisms

21 January 2018

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A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

21 January 2018

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Mitochondrial formation of reactive oxygen species

21 January 2018

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Mitochondrial oxidative stress can lead to nuclear hypermutability

21 January 2018

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coq7/clk-1 regulates mitochondrial respiration and the generation of reactive oxygen species via coenzyme Q.

21 January 2018

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PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

21 January 2018

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Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health

21 January 2018

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Dicarbonyl intermediates in the maillard reaction

21 January 2018

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Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and disease

21 January 2018

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The formation of methylglyoxal from triose phosphates. Investigation using a specific assay for methylglyoxal.

21 January 2018

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Alpha-oxoaldehyde metabolism and diabetic complications

21 January 2018

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Glyoxalase I--structure, function and a critical role in the enzymatic defence against glycation

21 January 2018

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Peptide mapping identifies hotspot site of modification in human serum albumin by methylglyoxal involved in ligand binding and esterase activity

21 January 2018

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Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans

21 January 2018

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C. elegans as model for the study of high glucose- mediated life span reduction

21 January 2018

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N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins

21 January 2018

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Protein glycation, diabetes, and aging

21 January 2018

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The role of AGEs in aging: causation or correlation

21 January 2018

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Prevention of cardiovascular and renal pathology of aging by the advanced glycation inhibitor aminoguanidine.

21 January 2018

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Identifying advanced glycation end products as a major source of oxidants in aging: implications for the management and/or prevention of reduced renal function in elderly persons

21 January 2018

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Does accumulation of advanced glycation end products contribute to the aging phenotype?

21 January 2018

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Understanding RAGE, the receptor for advanced glycation end products

21 January 2018

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Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications

21 January 2018

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Structural basis for pattern recognition by the receptor for advanced glycation end products (RAGE).

21 January 2018

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N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression

21 January 2018

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Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB

21 January 2018

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Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end products

21 January 2018

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RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes.

21 January 2018

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Accumulation of alpha-oxoaldehydes during oxidative stress: a role in cytotoxicity

21 January 2018

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Insulin improves myocardial blood flow in patients with type 2 diabetes and coronary artery disease

21 January 2018

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Epigenetic factors in aging and longevity

21 January 2018

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The role of epigenetics in aging and age-related diseases

21 January 2018

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Genetic and epigenetic regulation of aging

21 January 2018

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Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions.

21 January 2018

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Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail

21 January 2018

1 reference

Phenotypic plasticity and selection in Drosophila life-history evolution. I. Nutrition and the cost of reproduction

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000322087

1 reference

23 August 2017

1 reference

PubMed ID

20962515