Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses (Q24619395)

1

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Huei-sheng Vincent Chen

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Dongxian Zhang

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Stuart A Lipton

Taking the time to study competitive antagonism

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language of work or name

English

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publication date

18 August 2010

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published in

Journal of Neuroscience

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volume

30

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issue

33

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page(s)

11246-50

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cites work

1 reference

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Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism

7 April 2017

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Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

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The chemical biology of clinically tolerated NMDA receptor antagonists

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The glutamate receptor ion channels

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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

7 April 2017

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Magnesium gates glutamate-activated channels in mouse central neurones

7 April 2017

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Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

7 April 2017

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Mg2+ imparts NMDA receptor subtype selectivity to the Alzheimer's drug memantine

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Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

27 September 2017

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Pathologically activated therapeutics for neuroprotection

27 September 2017

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Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels

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NMDA channel blockers: memantine and amino-aklylcyclohexanes--in vivo characterization

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Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells

27 September 2017

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Excitatory amino acids as a final common pathway for neurologic disorders.

27 September 2017

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Prospects for clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide

27 September 2017

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Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines

27 September 2017

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Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

27 September 2017

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Glutamate neurotoxicity and diseases of the nervous system

27 September 2017

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Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels

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Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

27 September 2017

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Evidence that the loss of the voltage-dependent Mg2+ block at the N-methyl-D-aspartate receptor underlies receptor activation during inhibition of neuronal metabolism

27 September 2017

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Actions of ketamine, phencyclidine and MK-801 on NMDA receptor currents in cultured mouse hippocampal neurones

27 September 2017

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Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation.

27 September 2017

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Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists

30 May 2018

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12 December 2020

Epileptiform activity in microcultures containing small numbers of hippocampal neurons.

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30 May 2018

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Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.

30 May 2018

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NMDA receptor activity regulates transcription of antioxidant pathways

28 November 2018

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Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes

28 November 2018

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Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons

28 November 2018

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Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial

28 November 2018

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Paradigm shift in neuroprotective drug development: clinically tolerated NMDA receptor inhibition by memantine

28 November 2018

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Activation of NMDA receptors in rat dentate gyrus granule cells by spontaneous and evoked transmitter release.

28 November 2018

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Memantine in moderate-to-severe Alzheimer's disease

28 November 2018

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Brain penetration and in vivo recovery of NMDA receptor antagonists amantadine and memantine: a quantitative microdialysis study.

28 November 2018

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28 November 2018

1 reference

12 December 2020

Nonuniform probability of glutamate release at a hippocampal synapse

1 reference

PubMed

12 December 2020

10.1523/JNEUROSCI.2488-10.2010

Identifiers

DOI

1 reference

3605573

3605573

1 reference

1 reference

1 reference