The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease (Q34268122)

1 August 2017

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title

The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease (English)

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1 August 2017

The Neuropharmacological Basis for the Use of Memantine in the Treatment of Alzheimer's Disease (English)

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Michael A Rogawski

1

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1 August 2017

Gary L Wenk

series ordinal

2

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1 August 2017

Michael A. Rogawski

series ordinal

1

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Gary L. Wenk

series ordinal

2

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publication date

1 January 2003

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CNS Neuroscience & Therapeutics

1 August 2017

7 June 2006

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published in

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1 August 2017

volume

9

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1 August 2017

issue

3

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1 August 2017

page(s)

275-308

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Alternative excitotoxic hypotheses

1 August 2017

cites work

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https://api.crossref.org/works/10.1111%2FJ.1527-3458.2003.TB00254.X

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate

21 January 2018

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Trapping of glutamate and glycine during open channel block of rat hippocampal neuron NMDA receptors by 9‐aminoacridine

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1527-3458.2003.TB00254.X

Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells

21 January 2018

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Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism

21 January 2018

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Increased glutamate in CSF and plasma of patients with HIV dementia

21 January 2018

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Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1527-3458.2003.TB00254.X

Abnormalities of neural circuitry in Alzheimer's disease: hippocampus and cortical cholinergic innervation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1527-3458.2003.TB00254.X

Cholinesterase inhibitor therapy stabilizes symptoms of Alzheimer disease

21 January 2018

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Delayed neurotoxicity of excitatory amino acids in vitro

21 January 2018

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Influenza a virus M2 ion channel activity is essential for efficient replication in tissue culture

21 January 2018

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Impairment of active avoidance response in rats with continuous infusion of quinolinic acid into the lateral ventricle

21 January 2018

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The glutamate receptor ion channels

21 January 2018

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12 December 2020

Amino-alkyl-cyclohexanes are novel uncompetitive NMDA receptor antagonists with strong voltage-dependency and fast blocking kinetics: in vitro and in vivo characterization

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12 December 2020

NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines

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12 December 2020

The role of excitotoxicity in neurodegenerative disease: implications for therapy

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12 December 2020

Brain penetration and in vivo recovery of NMDA receptor antagonists amantadine and memantine: a quantitative microdialysis study

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12 December 2020

Clinical experience with oral ketamine

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12 December 2020

Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data

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12 December 2020

Memantine restores long term potentiation impaired by tonic N-methyl-D-aspartate (NMDA) receptor activation following reduction of Mg2+ in hippocampal slices

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12 December 2020

Long-term potentiation--a decade of progress?

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12 December 2020

Behavioral effects and anticonvulsant efficacies of low-affinity, uncompetitive NMDA antagonists in mice.

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12 December 2020

Toying with memory in the hippocampus.

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12 December 2020

No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use.

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12 December 2020

D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor

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12 December 2020

L-glutamate, L-arginine and L-citrulline levels in cerebrospinal fluid of Parkinson's disease, multiple system atrophy, and Alzheimer's disease patients

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12 December 2020

A prospective PMS study to validate the sensitivity for change of the D-scale in advanced stages of dementia using the NMDA-antagonist memantine.

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12 December 2020

Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine).

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12 December 2020

Poly(ADP-ribose) polymerase-1 in the nervous system

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12 December 2020

Transient NMDA receptor inactivation provides long-term protection to cultured cortical neurons from a variety of death signals

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12 December 2020

Low affinity channel blocking (uncompetitive) NMDA receptor antagonists as therapeutic agents--toward an understanding of their favorable tolerability

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12 December 2020

Evaluation of memantine for neuroprotection in dementia

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12 December 2020

Effects of pharmacologically induced changes in NMDA-receptor activity on long-term memory in humans

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12 December 2020

Modulation of learning processes by ionotropic glutamate receptor ligands.

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12 December 2020

CA1-specific N-methyl-D-aspartate receptor knockout mice are deficient in solving a nonspatial transverse patterning task

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12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

Structural modifications to an N-methyl-D-aspartate receptor antagonist result in large differences in trapping block

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12 December 2020

Molecular organization of the postsynaptic specialization

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12 December 2020

Competitive and noncompetitive NMDA antagonist effects in rats trained to discriminate lever-press counts.

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12 December 2020

Channel blockers acting at N-methyl-D-aspartate receptors: differential effects of mutations in the vestibule and ion channel pore.

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12 December 2020

Tau is essential to beta -amyloid-induced neurotoxicity

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12 December 2020

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

1 reference

12 December 2020

Excited to death: different ways to lose your neurones

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12 December 2020

Mechanism of membrane depolarization caused by the Alzheimer Abeta1-42 peptide

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12 December 2020

Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death

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12 December 2020

NMDA receptor pathways as drug targets

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12 December 2020

A double-blind, placebo-controlled multicentre study of memantine in mild to moderate vascular dementia (MMM500).

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12 December 2020

Energetics and oxidative stress in synaptic plasticity and neurodegenerative disorders

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12 December 2020

New life in an old idea: the synaptic plasticity and memory hypothesis revisited

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12 December 2020

Reactive oxygen: its sources and significance in Alzheimer disease.

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12 December 2020

Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40).

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12 December 2020

Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis

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12 December 2020

Memantine for dementia

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12 December 2020

Differential regulation of glutamate receptors in Alzheimer's disease

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12 December 2020

Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy

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12 December 2020

Glutamate receptor function in learning and memory

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12 December 2020

Memantine in moderate-to-severe Alzheimer's disease

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12 December 2020

Cholinesterases: new roles in brain function and in Alzheimer's disease

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12 December 2020

Pharmacological modulation of perceptual learning and associated cortical reorganization

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12 December 2020

Studies on the mechanism of action of the antiparkinsonian drugs memantine and amantadine: no evidence for direct dopaminomimetic or antimuscarinic properties

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12 December 2020

Memantine stimulates inositol phosphates production in neurones and nullifies N-methyl-D-aspartate-induced destruction of retinal neurones

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12 December 2020

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

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12 December 2020

A dose-dependent increase of Tau immunostaining is produced by glutamate toxicity in primary neuronal cultures

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12 December 2020

Memantine in the treatment of mild to moderate dementia syndrome. A double-blind placebo-controlled study

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12 December 2020

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

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12 December 2020

Pharmacotoxic psychosis after memantine in Parkinson's disease

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12 December 2020

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

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12 December 2020

Efficacy and tolerability of memantine in patients with dementia syndrome. A double-blind, placebo controlled trial

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12 December 2020

Comparison of pharmacodynamic effects of the non-competitive NMDA receptor antagonists MK-801 and ketamine in pigs.

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12 December 2020

Memantine is highly potent in protecting cortical cultures against excitotoxic cell death evoked by glutamate and N-methyl-D-aspartate

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12 December 2020

Advances in Alzheimer's disease

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12 December 2020

Neurotoxicity induced by continuous infusion of quinolinic acid into the lateral ventricle in rats

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12 December 2020

Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

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12 December 2020

Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels

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12 December 2020

Low-frequency activation of the NMDA receptor system can prevent the induction of LTP

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12 December 2020

Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs

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12 December 2020

Memantine displaces [3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex

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12 December 2020

Systemically administered N-methyl-D-aspartate interferes with acquisition of a passive avoidance response in rats.

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12 December 2020

Glutamate neurotoxicity in cortical cell culture.

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12 December 2020

Effects of memantine on the frog neuromuscular junction

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12 December 2020

Amnesic effect of the novel anticonvulsant MK-801.

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12 December 2020

Effects of intravenous administration of memantine in parkinsonian patients (author's transl)

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12 December 2020

Memantine (1-amino-3,5-dimethyladamantane) blocks the serotonin-induced depolarization response in a neuronal cell line

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12 December 2020

Memantine in the treatment of senile dementia of the Alzheimer type.

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12 December 2020

Dissociation between components of spatial memory in rats after recovery from the effects of retrohippocampal lesions

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12 December 2020

Ionic Blockage of Sodium Channels in Nerve

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12 December 2020

Amantadine in Parkinson's disease. Review of more than two years' experience

1 reference

12 December 2020

[Effects of oral memantine administration on Parkinson symptoms. Results of a placebo-controlled multicenter study]

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12 December 2020

Behavioral and neurochemical effects following neurotoxic lesions of a major cholinergic input to the cerebral cortex in the rat.

1 reference

12 December 2020

[Valve of symptomatic therapy with memantine in cerebral coma. II. Development of stretch synergisms in coma with brain stem symptoms]

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12 December 2020

Memantine and neurogenic bladder disorders within the bounds of spastic conditions

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12 December 2020

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12 December 2020

Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

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12 December 2020

Cerebrospinal fluid and serum concentrations of the N-methyl-D-aspartate (NMDA) receptor antagonist memantine in man.

1 reference

12 December 2020

Noncompetitive NMDA receptor antagonists with fast open-channel blocking kinetics and strong voltage-dependency as potential therapeutic agents for Alzheimer's dementia

1 reference

12 December 2020

Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines

1 reference

12 December 2020

Inhibition of Glutamate-induced Neurotoxicity by a Tau Antisense Oligonucleotide in Primary Culture of Rat Cerebellar Granule Cells

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12 December 2020

AMPA receptor antagonism attenuates MK-801-induced hypermetabolism in the posterior cingulate cortex

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12 December 2020

Investigations of neurotoxicity and neuroprotection within the nucleus basalis of the rat.

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12 December 2020

Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits.

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12 December 2020

Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties.

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12 December 2020

Excitatory amino acids as a final common pathway for neurologic disorders.

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12 December 2020

Neuroprotective NMDA antagonists: the controversy over their potential for adverse effects on cortical neuronal morphology

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12 December 2020

N-methyl-D-aspartic acid receptor structure and function

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12 December 2020

Delayed administration of memantine prevents N-methyl-D-aspartate receptor-mediated neurotoxicity

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12 December 2020

The nature and time course of neuronal vacuolation induced by the N-methyl-D-aspartate antagonist MK-801.

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12 December 2020

Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan).

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12 December 2020

Hydrophobic interactions of n-alkyl diamines with the N-methyl-D-aspartate receptor: voltage-dependent and -independent blocking sites

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12 December 2020

Staging of Alzheimer-related cortical destruction

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12 December 2020

A synaptic model of memory: long-term potentiation in the hippocampus

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12 December 2020

Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo

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12 December 2020

CSF excitatory amino acids and severity of illness in Alzheimer's disease

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12 December 2020

beta-Amyloid-(1-40) increases long-term potentiation in rat hippocampus in vitro

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12 December 2020

MK-801, memantine and amantadine show neuroprotective activity in the nucleus basalis magnocellularis

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12 December 2020

Learning deficits induced by chronic intraventricular infusion of quinolinic acid--protection by MK-801 and memantine

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12 December 2020

Evolution of the neuropathology of Alzheimer's disease.

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12 December 2020

Developmental and regional expression of NMDA receptor subtypes containing the NR2D subunit in rat brain.

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12 December 2020

Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines.

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12 December 2020

The effects of mitochondrial failure upon cholinergic toxicity in the nucleus basalis

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12 December 2020

Discriminative stimulus effects of the NMDA receptor antagonists MK-801 and CGP 37849 in rats.

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12 December 2020

NMDA antagonist blockade of AT8 tau immunoreactive changes in neuronal cultures

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12 December 2020

Determination of intracellular Ca2+ concentration can be a useful tool to predict neuronal damage and neuroprotective properties of drugs

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12 December 2020

Infusion of (+) -MK-801 and memantine -- contrasting effects on radial maze learning in rats with entorhinal cortex lesion.

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12 December 2020

MK-801 neurotoxicity in male mice: histologic effects and chronic impairment in spatial learning.

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12 December 2020

Effects of the uncompetitive NMDA receptor antagonist memantine on hippocampal long-term potentiation, short-term exploratory modulation and spatial memory in awake, freely moving rats.

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12 December 2020

Postischemic therapy with MK-801 (dizocilpine) in a primate model of transient focal brain ischemia

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12 December 2020

Is infantile alternating hemiplegia mediated by glutamate toxicity and can it be treated with memantine?

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12 December 2020

Drug therapy for acquired pendular nystagmus in multiple sclerosis

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12 December 2020

Psychotogenicity and N-methyl-D-aspartate receptor antagonism: implications for neuroprotective pharmacotherapy.

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12 December 2020

Neuroprotection of acetylcholinergic basal forebrain neurons by memantine and neurokinin B.

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12 December 2020

Dizocilpine-like discriminative stimulus effects of low-affinity uncompetitive NMDA antagonists.

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12 December 2020

Apparent independent action of nimodipine and glutamate antagonists to protect cultured neurons against glutamate-induced damage

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12 December 2020

Trapping channel block of NMDA-activated responses by amantadine and memantine

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12 December 2020

Modifications of neuronal phosphorylated tau immunoreactivity induced by NMDA toxicity

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12 December 2020

Oxidative stress hypothesis in Alzheimer's disease

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12 December 2020

Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents--preclinical studies.

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12 December 2020

Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP.

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12 December 2020

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

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12 December 2020

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

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12 December 2020

Effects of beta-amyloid-(25-35) peptides on radioligand binding to excitatory amino acid receptors and voltage-dependent calcium channels: evidence for a selective affinity for the glutamate and glycine recognition sites of the NMDA receptor

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12 December 2020

Open-channel blockers at the human alpha4beta2 neuronal nicotinic acetylcholine receptor

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12 December 2020

Neurotransmitter amino acids in cerebrospinal fluid of patients with Alzheimer's disease

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12 December 2020

Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation

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12 December 2020

Interaction of memantine and amantadine with agonist-unbound NMDA-receptor channels in acutely isolated rat hippocampal neurons

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12 December 2020

The NMDA antagonist model for schizophrenia: promise and pitfalls.

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12 December 2020

Cholinergic foundations of Alzheimer's disease therapy

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12 December 2020

Evaluation of the reinforcing and discriminative stimulus properties of the low-affinity N-methyl-D-aspartate channel blocker memantine.

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12 December 2020

Differences in degree of trapping of low-affinity uncompetitive N-methyl-D-aspartic acid receptor antagonists with similar kinetics of block.

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12 December 2020

Alzheimer's disease: genetic studies and transgenic models

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12 December 2020

Glutamate toxicity in chronic neurodegenerative disease.

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12 December 2020

10.1111/J.1527-3458.2003.TB00254.X

Identifiers

DOI

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PMC publication ID

6741669

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1 reference