Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model (Q24624879)

23 June 2017

title

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model (English)

1 reference

23 June 2017

1 reference

1 reference

3

Laure Verret

1 reference

23 June 2017

11

Lennart Mucke

1 reference

23 June 2017

Pascal E Sanchez

1

1 reference

23 June 2017

Lei Zhu

2

1 reference

23 June 2017

Keith A Vossel

4

1 reference

23 June 2017

Anna G Orr

5

1 reference

23 June 2017

John R Cirrito

6

1 reference

23 June 2017

Nino Devidze

7

1 reference

23 June 2017

Kaitlyn Ho

8

1 reference

23 June 2017

Gui-Qiu Yu

9

1 reference

23 June 2017

Jorge J Palop

10

1 reference

23 June 2017

language of work or name

English

0 references

publication date

6 August 2012

1 reference

Proceedings of the National Academy of Sciences of the United States of America

23 June 2017

published in

1 reference

23 June 2017

volume

109

1 reference

23 June 2017

issue

42

1 reference

23 June 2017

page(s)

E2895-903

1 reference

Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model

23 June 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Alzheimer mechanisms and therapeutic strategies

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

SV2 renders primed synaptic vesicles competent for Ca2+ -induced exocytosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Synaptic vesicle protein 2 enhances release probability at quiescent synapses

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Effect of levetiracetam on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl3 injection

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

APP processing and synaptic function

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment

26 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Levetiracetam: a review of its use in epilepsy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Hippocampal interictal spikes disrupt cognition in rats

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

The dysregulation of intracellular calcium in Alzheimer disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Functional alterations in memory networks in early Alzheimer's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Key factors in the discovery and development of new antiepileptic drugs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Targeting Abeta and tau in Alzheimer's disease, an early interim report

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Amyloid deposition is associated with impaired default network function in older persons without dementia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Calcium signaling and neurodegenerative diseases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Epilepsy and cognitive impairments in Alzheimer disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Levetiracetam: part II, the clinical profile of a novel anticonvulsant drug

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Levetiracetam: the profile of a novel anticonvulsant drug-part I: preclinical data.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

A network dysfunction perspective on neurodegenerative diseases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Cognitive impairment during epileptiform discharges: is it ever justifiable to treat the EEG?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Seizures in elderly patients with dementia: epidemiology and management

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Neuropsychological effects of epilepsy and antiepileptic drugs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Levetiracetam has a time- and stimulation-dependent effect on synaptic transmission

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Development of tolerance during chronic treatment of kindled rats with the novel antiepileptic drug levetiracetam.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Neuroscience: Alzheimer's disease

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Development of tolerance to levetiracetam in rats with chronic epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Evidence for sustained efficacy of levetiracetam as add-on epilepsy therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Levetiracetam reduces caffeine-induced Ca2+ transients and epileptiform potentials in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

EEG-triggered functional MRI of interictal epileptiform activity in patients with partial seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

EEG-fMRI of epileptic spikes: concordance with EEG source localization and intracranial EEG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Temporal and extratemporal BOLD responses to temporal lobe interictal spikes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of Alzheimer's disease: depletion of calcium-dependent proteins and inhibitory hippocampal remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1121081109

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

Effects of distinct classes of N-methyl-D-aspartate receptor antagonists on seizures, axonal sprouting and neuronal loss in vitro: suppression by NR2B-selective antagonists

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

In VivoAssessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479491

28 November 2018

Identifiers

DOI

10.1073/PNAS.1121081109

1 reference

OpenCitations bibliographic resource ID

23 June 2017

0 references

1721352

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1721352

1 reference