A network dysfunction perspective on neurodegenerative diseases (Q36628146)

15 August 2017

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title

A network dysfunction perspective on neurodegenerative diseases (English)

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15 August 2017

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3

Lennart Mucke

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15 August 2017

Jorge J Palop

1

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15 August 2017

Jeannie Chin

series ordinal

2

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15 August 2017

language of work or name

English

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publication date

1 October 2006

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15 August 2017

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15 August 2017

443

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15 August 2017

768-773

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15 August 2017

7113

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https://scigraph.springernature.com/pub.10.1038/nature05289

15 August 2017

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cites work

Prospects for neurology and psychiatry

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Fluctuating cognition in dementia with Lewy bodies and Alzheimer's disease is qualitatively distinct

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

The Clinician Assessment of Fluctuation and the One Day Fluctuation Assessment Scale

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Quantifying fluctuation in dementia with Lewy bodies, Alzheimer's disease, and vascular dementia

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Delirium in dementia.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Life and death of neurons in the aging brain

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Motor score of the Unified Parkinson Disease Rating Scale as a good predictor of Lewy body-associated neuronal loss in the substantia nigra.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Antipsychotic Drug-Induced Movement Disorders

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Antibasal ganglia antibodies and their relevance to movement disorders

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Is your brain really necessary?

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Nervous system reorganization following injury

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Presymptomatic compensation in Parkinson's disease is not dopamine-mediated

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

What is cognitive reserve? Theory and research application of the reserve concept

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Cognitive strategies dependent on the hippocampus and caudate nucleus in human navigation: variability and change with practice.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Routes to remembering: the brains behind superior memory

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Neurovascular mechanisms of Alzheimer's neurodegeneration

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Degeneracy and complexity in biological systems

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Plasticity of the nigropallidal pathway in Parkinson's disease.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Deciphering the molecular basis of memory failure in Alzheimer's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Modulation of neurodegeneration by molecular chaperones

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Anticonvulsants attenuate amyloid beta-peptide neurotoxicity, Ca2+ deregulation, and cytoskeletal pathology

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Inflammation in neurodegenerative disease--a double-edged sword

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Mitochondria take center stage in aging and neurodegeneration

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Alzheimer's disease and Abeta toxicity: from top to bottom

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Pathways towards and away from Alzheimer's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Pharmaceutical, cellular and genetic therapies for Huntington's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Pathology of presynaptic proteins in Alzheimer's disease: more than simple loss of terminals.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Genetic mouse models of Huntington's and Parkinson's diseases: illuminating but imperfect

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Gene-environment interactions, neuronal dysfunction and pathological plasticity in Huntington's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Pouring oil into the fire? On the conundrum of the beneficial effects of NMDA receptor antagonists in Alzheimer disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Molecular profile of reactive astrocytes--implications for their role in neurologic disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Impaired cross-modal inhibition in Alzheimer disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Septal networks: relevance to theta rhythm, epilepsy and Alzheimer's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Inhibitory neuronal activity can compensate for adverse effects of beta-amyloid in hippocampal neurons.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Do acetylcholinesterase inhibitors boost synaptic scaling in Alzheimer's disease?

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

https://api.crossref.org/works/10.1038%2FNATURE05289

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7 January 2021

Cognitive decline in severe intractable epilepsy

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Mortality of epilepsy in developed countries: a review

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Present and future drug treatment for Parkinson's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Current pharmacotherapy for Alzheimer's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Functional neurochemistry of Alzheimer's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Juvenile onset Huntington's disease--clinical and research perspectives.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Can alzheimer's disease and dementias with Lewy bodies be distinguished clinically?

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Incidence and predictors of seizures in patients with Alzheimer's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Increased seizure threshold and severity in young transgenic CRND8 mice

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Calcium-regulated signaling pathways: role in amyloid beta-induced synaptic dysfunction

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer's disease.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Alzheimer's patients engage an alternative network during a memory task.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Synaptic mechanisms of the cerebellar cortical network

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Behavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Reversible memory loss in a mouse transgenic model of Alzheimer's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Tau alteration and neuronal degeneration in tauopathies: mechanisms and models

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Tau suppression in a neurodegenerative mouse model improves memory function

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Cell adhesion molecules in neural plasticity and pathology: similar mechanisms, distinct organizations?

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Regulation of NMDA receptor trafficking by amyloid-beta

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

The role of nicotinic acetylcholine receptors in Alzheimer's disease

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Mitogen-activated protein kinases and the evolution of Alzheimer's: a revolutionary neurogenetic axis for therapeutic intervention?

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Tau and src family tyrosine kinases

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Is there a role of the cyclin-dependent kinase 5 activator p25 in Alzheimer's disease?

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Dendrite and dendritic spine alterations in Alzheimer models

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

APP processing and synaptic function

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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https://api.crossref.org/works/10.1038%2FNATURE05289

7 January 2021

Identifiers

DOI

10.1038/NATURE05289

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Dimensions Publication ID

15 August 2017

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