Phase I trial of "bi-shRNAi(furin)/GMCSF DNA/autologous tumor cell" vaccine (FANG) in advanced cancer (Q24625197)

1

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Minal Barve

2

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Joseph Kuhn

3

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Anton Melnyk

4

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Peter Beitsch

5

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Martin Lazar

6

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Samuel Lifshitz

7

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Mitchell Magee

8

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Jonathan Oh

9

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Susan W Mill

10

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Cynthia Bedell

11

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Candice Higgs

12

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Padmasini Kumar

13

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Yang Yu

14

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Fabienne Norvell

15

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Connor Phalon

16

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Nicolas Taquet

17

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Donald D Rao

18

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Zhaohui Wang

19

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Chris M Jay

20

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Beena O Pappen

21

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Gladice Wallraven

22

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F Charles Brunicardi

23

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David M Shanahan

24

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Phillip B Maples

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

25

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language of work or name

English

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publication date

March 2012

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published in

Molecular Therapy

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volume

20

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page(s)

679-86

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issue

3

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cites work

1 reference

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7 April 2017

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Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria

7 April 2017

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Transforming growth factor-beta regulation of immune responses

7 April 2017

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The proprotein convertases furin and PACE4 play a significant role in tumor progression

7 April 2017

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Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers

7 April 2017

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Immunosuppressive networks in the tumour environment and their therapeutic relevance

7 April 2017

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The polarization of immune cells in the tumour environment by TGFbeta

7 April 2017

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Interactions between the immune system and cancer: a brief review of non-spatial mathematical models

27 September 2017

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The immune response during acute HIV-1 infection: clues for vaccine development

27 September 2017

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27 September 2017

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Immunosuppressive networks in the tumour environment and their effect in dendritic cells

27 September 2017

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Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing.

27 September 2017

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Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer

27 September 2017

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Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity

27 September 2017

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Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma.

27 September 2017

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Inhibition of TGFbeta signaling in cancer therapy

27 September 2017

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Alterations in components of the TGF-beta superfamily signaling pathways in human cancer

27 September 2017

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TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

27 September 2017

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Proprotein convertases: "master switches" in the regulation of tumor growth and progression

27 September 2017

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TGF-beta: the perpetrator of immune suppression by regulatory T cells and suicidal T cells

27 September 2017

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Dendritic Cell Function in Vivo during the Steady State: A Role in Peripheral Tolerance

27 September 2017

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27 September 2017

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Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

27 September 2017

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Mechanism of inhibition of LPS-induced IL-12p40 production by IL-10 and TGF-beta in ANA-1 cells.

27 September 2017

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Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours

27 September 2017

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TGFbeta1 regulates gene expression of its own converting enzyme furin

27 September 2017

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Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy

27 September 2017

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Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

27 September 2017

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Factors, including transforming growth factor beta, released in the glioblastoma residual cavity, impair activity of adherent lymphokine-activated killer cells.

30 May 2018

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PROVENGE (Sipuleucel-T) in prostate cancer: the first FDA-approved therapeutic cancer vaccine.

28 July 2018

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Adaptive immunity maintains occult cancer in an equilibrium state

28 November 2018

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Cancer immunotherapy, mathematical modeling and optimal control.

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Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance.

28 November 2018

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28 November 2018

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Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma.

28 November 2018

1 reference

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Deletion, but not anergy, is involved in TGF-beta-treated antigen-presenting cell-induced tolerance.

28 November 2018

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Elevated furin expression in aggressive human head and neck tumors and tumor cell lines

28 November 2018

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Transforming growth factor-beta inhibits interferon-gamma secretion by lymphokine-activated killer cells stimulated with tumor cells.

28 November 2018

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The TGF-beta family of growth and differentiation factors.

28 November 2018

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Multifunctional vaccines in cancer: the 'triad' approach

28 November 2018

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12 December 2020

Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness

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12 December 2020

Transforming growth factor-beta: biological function and chemical structure

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12 December 2020

Contrasting effects of TGF-beta 1 and TNF-alpha on the development of dendritic cells from progenitors in mouse bone marrow

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12 December 2020

TGF-beta promotes immune deviation by altering accessory signals of antigen-presenting cells

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12 December 2020

Phase I trial of TGF-beta 2 antisense GM-CSF gene-modified autologous tumor cell (TAG) vaccine

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12 December 2020

Identifiers

DOI

10.1038/MT.2011.269

1 reference

3792132

3792132

1 reference

1 reference

1 reference