Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer (Q36516410)

14 August 2017

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title

Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer (English)

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14 August 2017

1

Brian Bierie

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Harold L. Moses

series ordinal

2

object named as

Harold L Moses

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PubMed ID

16794634

14 August 2017

language of work or name

English

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publication date

1 July 2006

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14 August 2017

Nature Reviews Cancer

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14 August 2017

6

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14 August 2017

7

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14 August 2017

506-520

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https://scigraph.springernature.com/pub.10.1038/nrc1926

14 August 2017

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cites work

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

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Expression cloning and characterization of the TGF-beta type III receptor

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The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

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Thrombospondin-1 is a major activator of TGF-beta1 in vivo

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Oligomeric structure of type I and type II transforming growth factor beta receptors: homodimers form in the ER and persist at the plasma membrane

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Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

31 March 2020

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TGF beta signals through a heteromeric protein kinase receptor complex

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Signaling by chimeric erythropoietin-TGF-beta receptors: homodimerization of the cytoplasmic domain of the type I TGF-beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction.

31 March 2020

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Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors

31 March 2020

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Transforming growth factor-beta stimulates epithelial-mesenchymal transformation in the proepicardium

31 March 2020

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

31 March 2020

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Non-Smad TGF-beta signals

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High-throughput mapping of a dynamic signaling network in mammalian cells

31 March 2020

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Specificity and versatility in tgf-beta signaling through Smads

31 March 2020

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How cells read TGF-beta signals

31 March 2020

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TGF-beta signaling in tumor suppression and cancer progression

31 March 2020

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Cytoplasmic PML function in TGF-beta signalling

31 March 2020

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A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure

31 March 2020

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Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42.

31 March 2020

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TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

31 March 2020

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Cell-Type-Specific Activation of PAK2 by Transforming Growth Factor β Independent of Smad2 and Smad3

31 March 2020

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Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase.

31 March 2020

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Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

31 March 2020

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Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

31 March 2020

1 reference

TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction

31 March 2020

1 reference

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

31 March 2020

1 reference

TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest

31 March 2020

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Alterations in components of the TGF-beta superfamily signaling pathways in human cancer

31 March 2020

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Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

31 March 2020

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Genomic instability and colon cancer

31 March 2020

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Role of transforming growth factor beta in cancer

31 March 2020

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Mutation frequency in coding and non-coding repeat sequences in mismatch repair deficient cells derived from normal human tissue

31 March 2020

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Molecular mechanisms of inactivation of TGF-beta receptors during carcinogenesis

31 March 2020

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Transcriptional repression of the transforming growth factor-beta type I receptor gene by DNA methylation results in the development of TGF-beta resistance in human gastric cancer

31 March 2020

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TGF-beta receptor function in the endothelium.

31 March 2020

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Genetic models for transforming growth factor beta superfamily signaling in ovarian follicle development

31 March 2020

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Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

31 March 2020

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Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

31 March 2020

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Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice

31 March 2020

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Information networks in the mammary gland.

31 March 2020

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Generation of a functional mammary gland from a single stem cell

31 March 2020

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Overexpression of a kinase-deficient transforming growth factor-beta type II receptor in mouse mammary stroma results in increased epithelial branching

31 March 2020

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Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.

31 March 2020

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Reducing mammary cancer risk through premature stem cell senescence.

31 March 2020

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Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-beta1 expression

31 March 2020

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Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation.

31 March 2020

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Ectopic TGF beta 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population

31 March 2020

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Mammary tumor suppression by transforming growth factor beta 1 transgene expression

31 March 2020

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Increased Malignancy of Neu-Induced Mammary Tumors Overexpressing Active Transforming Growth Factor β1

31 March 2020

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Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors

31 March 2020

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Transgenic Mice Expressing a Dominant-Negative Mutant Type II Transforming Growth Factor-β Receptor Exhibit Impaired Mammary Development and Enhanced Mammary Tumor Formation

31 March 2020

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Expression of TGF‐β type II receptor antisense RNA impairs TGF‐β signaling in vitro and promotes mammary gland differentiation in vivo

31 March 2020

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Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.

31 March 2020

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Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis

31 March 2020

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Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation

31 March 2020

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Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice

31 March 2020

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TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression.

31 March 2020

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Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

31 March 2020

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TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

31 March 2020

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Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

31 March 2020

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The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells

31 March 2020

1 reference

TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

31 March 2020

1 reference

Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice

31 March 2020

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Expression of a dominant negative type II TGF-beta receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development

31 March 2020

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Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGFbetaRII.

31 March 2020

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Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis

31 March 2020

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Distinct mechanisms of TGF-beta1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis

31 March 2020

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Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition

31 March 2020

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TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

31 March 2020

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Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks

31 March 2020

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Diversity, topographic differentiation, and positional memory in human fibroblasts

31 March 2020

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TGF-beta regulates differentially the proliferation of fetal and adult human skin fibroblasts via the activation of PKA and the autocrine action of FGF-2.

31 March 2020

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TGF-beta: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression

31 March 2020

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Transforming growth factor-beta in T-cell biology

31 March 2020

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TGF-beta: the perpetrator of immune suppression by regulatory T cells and suicidal T cells

31 March 2020

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Controlling the angiogenic switch: a balance between two distinct TGF-b receptor signaling pathways

31 March 2020

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Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

31 March 2020

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Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

31 March 2020

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Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable

31 March 2020

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Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

31 March 2020

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Minimal effects on immune parameters following chronic anti-TGF-beta monoclonal antibody administration to normal mice.

31 March 2020

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Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

31 March 2020

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Development of TGF-beta signalling inhibitors for cancer therapy

31 March 2020

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CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer

31 March 2020

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Modulation of the immune response by transforming growth factor beta

31 March 2020

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Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

31 March 2020

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TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

31 March 2020

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Adoptive transfer of tumor-reactive transforming growth factor-beta-insensitive CD8+ T cells: eradication of autologous mouse prostate cancer.

31 March 2020

1 reference

Kinetic characterization of novel pyrazole TGF-beta receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition

31 March 2020

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The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta

31 March 2020

1 reference

Selective inhibitors of type I receptor kinase block cellular transforming growth factor-beta signaling.

31 March 2020

1 reference

SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.

31 March 2020

1 reference

SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo

31 March 2020

1 reference

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

31 March 2020

1 reference

Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-beta signaling in ErbB2/Neu-induced tumors from transgenic mice

31 March 2020

1 reference

Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1.

31 March 2020

1 reference

Integrin alpha1beta1 and transforming growth factor-beta1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy

31 March 2020

1 reference

A fully human antibody neutralising biologically active human TGFbeta2 for use in therapy

31 March 2020

1 reference

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer

31 March 2020

1 reference

Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy

31 March 2020

1 reference

Intracerebral and intrathecal infusion of the TGF-beta 2-specific antisense phosphorothioate oligonucleotide AP 12009 in rabbits and primates: toxicology and safety.

31 March 2020

1 reference

The significance of unstable chromosomes in colorectal cancer.

31 March 2020

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Cancer genes and the pathways they control

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis.

31 March 2020

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Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation

31 March 2020

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Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation

31 March 2020

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TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors

31 March 2020

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TGF-beta 1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells

31 March 2020

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Modulation of macrophage function by transforming growth factor beta, interleukin-4, and interleukin-10.

31 March 2020

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TGF-beta inhibits proliferation of and promotes differentiation of human promonocytic leukemia cells

31 March 2020

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Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation

31 March 2020

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Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF

31 March 2020

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Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta

31 March 2020

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Role of tyrosine phosphorylation in ligand-independent sequestration of CXCR4 in human primary monocytes-macrophages

31 March 2020

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TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules

31 March 2020

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Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

31 March 2020

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Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype

31 March 2020

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Transforming growth factor-beta 1 differentially regulates proliferation and MHC class-II antigen expression in forebrain and brainstem astrocyte primary cultures

31 March 2020

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Transforming growth factor beta 1, a potent chemoattractant for human neutrophils, bypasses classic signal-transduction pathways.

31 March 2020

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Regulation of the proinflammatory effects of Fas ligand (CD95L).

31 March 2020

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Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape

31 March 2020

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Prolonged survival of rats with intracranial C6 gliomas by treatment with TGF-beta antisense gene

31 March 2020

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inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NRC1926

1 reference

14 August 2017

1 reference

PubMed ID

16794634