Retroviral intasome assembly and inhibition of DNA strand transfer (Q24629737)

Gene Ontology release 2020-05-02

5

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Eugene Valkov

3

object named as

Eugene Valkov

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Stephen Hare

object named as

Stephen Hare

1

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Alan N Engelman

4

object named as

Alan Engelman

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author name string

Saumya Shree Gupta

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

2

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language of work or name

English

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publication date

11 March 2010

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published in

Nature

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volume

464

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issue

7286

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page(s)

232-6

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cites work

1 reference

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Solution structure of the N-terminal zinc binding domain of HIV-1 integrase

7 April 2017

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7 April 2017

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7 April 2017

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Refinement of macromolecular structures by the maximum-likelihood method

7 April 2017

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7 April 2017

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SOLVE and RESOLVE: automated structure solution and density modification

7 April 2017

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ESPript/ENDscript: Extracting and rendering sequence and 3D information from atomic structures of proteins

7 April 2017

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Use of TLS parameters to model anisotropic displacements in macromolecular refinement

7 April 2017

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7 April 2017

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27 September 2017

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Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis

7 April 2017

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HIV-1 IN inhibitors: 2010 update and perspectives

7 April 2017

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Piecing together the structure of retroviral integrase, an important target in AIDS therapy

27 September 2017

1 reference

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Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs

27 September 2017

1 reference

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Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor

27 September 2017

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Retroviral integrase superfamily: the structural perspective

27 September 2017

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Novel HIV-1 integrase inhibitors derived from quinolone antibiotics

27 September 2017

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Retroviral DNA integration: reaction pathway and critical intermediates

27 September 2017

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Retroviral DNA integration--mechanism and consequences

27 September 2017

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Structure/function insights into Tn5 transposition.

27 September 2017

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Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes

27 September 2017

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HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

27 September 2017

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27 September 2017

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27 September 2017

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Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking

27 September 2017

1 reference

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The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding.

27 September 2017

1 reference

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The DNA-binding domain of HIV-1 integrase has an SH3-like fold

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837123

LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837123

The HIV-1 integrase genotype strongly predicts raltegravir susceptibility but not viral fitness of primary virus isolates

30 May 2018

1 reference

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Identifying amino acid residues that contribute to the cellular-DNA binding site on retroviral integrase

28 November 2018

1 reference

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The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837123

Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837123

Target DNA capture by HIV-1 integration complexes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837123

HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20118915

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE08784

1 reference

Dimensions Publication ID

2119680

1037230253

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2119680

1 reference

1 reference

1 reference