Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor (Q30487128)

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21 January 2020

title

Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor (English)

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21 January 2020

14

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21 January 2020

author name string

Fabrice Michel

1

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21 January 2020

Corinne Crucifix

2

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21 January 2020

Florence Granger

3

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21 January 2020

Sylvia Eiler

4

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21 January 2020

Jean-François Mouscadet

5

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21 January 2020

Sergei Korolev

6

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21 January 2020

Julia Agapkina

7

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21 January 2020

Rustam Ziganshin

8

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21 January 2020

Marina Gottikh

9

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21 January 2020

Alexis Nazabal

10

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21 January 2020

Stéphane Emiliani

11

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21 January 2020

Richard Benarous

12

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21 January 2020

Dino Moras

13

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21 January 2020

Marc Ruff

15

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21 January 2020

language of work or name

English

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publication date

19 February 2009

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21 January 2020

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21 January 2020

volume

28

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21 January 2020

issue

7

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21 January 2020

page(s)

980-991

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A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

21 January 2020

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Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein

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20 June 2018

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Identification of the LEDGF/p75 binding site in HIV-1 integrase

20 June 2018

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Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

20 June 2018

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Major Conformational Change in the Complex SF3b upon Integration into the Spliceosomal U11/U12 di-snRNP as Revealed by Electron Cryomicroscopy

20 June 2018

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HIV-1 integrase crosslinked oligomers are active in vitro

20 June 2018

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Human cell proteins and human immunodeficiency virus DNA integration

20 June 2018

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20 June 2018

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Structure and function of HIV-1 integrase

20 June 2018

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Interaction between human immunodeficiency virus type 1 reverse transcriptase and integrase proteins

20 June 2018

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20 June 2018

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LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

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The structure of DNA in the nucleosome core

20 June 2018

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HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

20 June 2018

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Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking

20 June 2018

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Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity

20 June 2018

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20 June 2018

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20 June 2018

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Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex

20 June 2018

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20 June 2018

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Human immunodeficiency virus integrase directs integration to sites of severe DNA distortion within the nucleosome core

20 June 2018

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Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases

20 June 2018

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Catalytic domain of human immunodeficiency virus type 1 integrase: identification of a soluble mutant by systematic replacement of hydrophobic residues

20 June 2018

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Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

20 June 2018

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Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase

21 January 2018

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Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking.

21 January 2018

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Photo-cross-linking studies suggest a model for the architecture of an active human immunodeficiency virus type 1 integrase-DNA complex

21 January 2018

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Integration requires a specific interaction of the donor DNA terminal 5'-cytosine with glutamine 148 of the HIV-1 integrase flexible loop

21 January 2018

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Determinants of Mg2+-dependent activities of recombinant human immunodeficiency virus type 1 integrase

21 January 2018

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Processing of viral DNA ends channels the HIV-1 integration reaction to concerted integration.

21 January 2018

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NORMA: a tool for flexible fitting of high-resolution protein structures into low-resolution electron-microscopy-derived density maps.

21 January 2018

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Flexible multi-scale fitting of atomic structures into low-resolution electron density maps with elastic network normal mode analysis.

21 January 2018

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A three-dimensional model of the human immunodeficiency virus type 1 integration complex

21 January 2018

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On the fitting of model electron densities into EM reconstructions: a reciprocal-space formulation

21 January 2018

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Direct localization of the tRNA--anticodon interaction site on the Escherichia coli 30 S ribosomal subunit by electron microscopy and computerized image averaging

21 January 2018

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12 December 2020

The influence of DNA and nucleosome structure on integration events directed by HIV integrase

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12 December 2020

Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA

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Electron capture dissociation of singly and multiply phosphorylated peptides

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12 December 2020

HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer

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12 December 2020

Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design.

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12 December 2020

Identifiers

DOI

10.1038/EMBOJ.2009.41

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19229293%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19229293%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference