Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions (Q24629755)

11

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Yvonne Dombrowski

object named as

Yvonne Dombrowski

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author name string

Mark Peric

2

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Sarah Koglin

3

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Claudia Kammerbauer

4

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Christine Göss

5

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David Anz

6

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Maren Simanski

7

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Regine Gläser

8

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Jürgen Harder

9

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Thomas Ruzicka

12

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Robert Besch

13

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Jürgen Schauber

Science Translational Medicine

14

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language of work or name

English

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publication date

11 May 2011

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published in

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volume

3

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issue

82

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page(s)

82ra38

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An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

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7 April 2017

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7 April 2017

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7 April 2017

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The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

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Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis

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A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses

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NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury

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The psoriatic transcriptome closely resembles that induced by interleukin-1 in cultured keratinocytes: dominance of innate immune responses in psoriasis

27 September 2017

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Narrowband ultraviolet B treatment improves vitamin D balance and alters antimicrobial peptide expression in skin lesions of psoriasis and atopic dermatitis

30 May 2018

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Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.

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28 November 2018

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28 November 2018

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A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release

28 November 2018

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Pathogenic function of IL-1 beta in psoriasiform skin lesions of flaky skin (fsn/fsn) mice

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12 December 2020

Interleukin-1 from epithelial cells fosters T cell-dependent skin inflammation

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12 December 2020

The activity of caspase-1 is increased in lesional psoriatic epidermis

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12 December 2020

Immune modulation: IL-1, master mediator or initiator of inflammation

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12 December 2020

Successful Treatment of Generalized Pustular Psoriasis With the Interleukin-1-Receptor Antagonist Anakinra: Lack of Correlation With IL1RN Mutations

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12 December 2020

TNF, but Not IL-6 and IL-17, Is Crucial for the Development of T Cell-Independent Psoriasis-Like Dermatitis in Il1rn-/- Mice

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12 December 2020

10.1126/SCITRANSLMED.3002001

Identifiers

DOI

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2010396

2010396

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