Granzyme B cleavage of autoantigens in autoimmunity (Q24633095)

Cell Death & Differentiation

Europe PubMed Central

title

Granzyme B cleavage of autoantigens in autoimmunity (English)

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E Darrah

1

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A Rosen

series ordinal

2

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language of work or name

English

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publication date

April 2010

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published in

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volume

17

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page(s)

624-32

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issue

4

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cites work

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The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis

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Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis

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HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases

7 April 2017

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Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface

7 April 2017

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Novel conformation of histidyl-transfer RNA synthetase in the lung: the target tissue in Jo-1 autoantibody-associated myositis

7 April 2017

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Comprehensive mapping of HLA-A0201-restricted CD8 T-cell epitopes on PDC-E2 in primary biliary cirrhosis

7 April 2017

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Identification of human autoantibodies to the DNA ligase IV/XRCC4 complex and mapping of an autoimmune epitope to a potential regulatory region

7 April 2017

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Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen and is modulated by glycosylation

7 April 2017

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Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

7 April 2017

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Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis

7 April 2017

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At least three distinct B cell epitopes reside in the C-terminal half of La protein, as determined by a recombinant DNA approach

7 April 2017

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Biochemical and biophysical analyses of recombinant forms of human topoisomerase I

7 April 2017

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

7 April 2017

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Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma

7 April 2017

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The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1.

27 September 2017

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Myositis-specific autoantibodies: their clinical and pathogenic significance in disease expression

27 September 2017

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Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity

27 September 2017

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Human and mouse granzyme A induce a proinflammatory cytokine response.

27 September 2017

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Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Granzyme B: evidence for a role in the origin of myasthenia gravis

27 September 2017

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Death by a thousand cuts: granzyme pathways of programmed cell death

27 September 2017

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Pathogenic autoantibodies in systemic sclerosis.

27 September 2017

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La autoantigen translocates to cytoplasm after cleavage during granzyme B-mediated cytotoxicity.

27 September 2017

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MMDB: annotating protein sequences with Entrez's 3D-structure database

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Primer: mechanisms of immunologic tolerance

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Detection of apoptosis-specific autoantibodies directed against granzyme B-induced cleavage fragments of the SS-B (La) autoantigen in sera from patients with primary Sjögren's syndrome.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.

27 September 2017

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Anti-Sm and anti-RNP antibodies.

27 September 2017

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Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Altered structure of autoantigens during apoptosis

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Unique conformation of cancer autoantigen B23 in hepatoma: a mechanism for specificity in the autoimmune response

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Mhc-guided processing: binding of large antigen fragments

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Apoptosis of the teratocarcinoma cell line Tera-1 leads to the cleavage of HERV-K10gag proteins by caspases and/or granzyme B.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Recognition of Granzyme B-generated autoantigen fragments in scleroderma patients with ischemic digital loss

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Identification of AHNAK as a novel autoantigen in systemic lupus erythematosus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

The tumor-infiltrating B cell response in medullary breast cancer is oligoclonal and directed against the autoantigen actin exposed on the surface of apoptotic cancer cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Control of antigen presentation by a single protease cleavage site

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Definition and redesign of the extended substrate specificity of granzyme B.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Differential expression of perforin in muscle-infiltrating T cells in polymyositis and dermatomyositis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

T cell receptor repertoire in polymyositis: clonal expansion of autoaggressive CD8+ T cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Dominance and crypticity of T cell antigenic determinants

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Mapping of multiple B cell epitopes on the 70-kilodalton autoantigen of the U1 ribonucleoprotein complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Nucleolar antigens and autoantibodies in hepatocellular carcinoma and other malignancies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Local protein instability predictive of helper T-cell epitopes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Anti-Jo-1 antibody: a marker for myositis with interstitial lung disease

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Autoantibodies of primary biliary cirrhosis recognize dihydrolipoamide acetyltransferase and inhibit enzyme function

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

T-cell epitopes on the 70-kDa protein of the (U1)RNP complex in autoimmune rheumatologic disorders

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Medullary carcinoma of the breast: a clinicopathologic study with 10 year follow-up

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136751

Evaluation of topoisomerase-1-specific CD8+ T-cell response in systemic sclerosis.

30 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.197

Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.197

Novel fragments of the Sjögren's syndrome autoantigens alpha-fodrin and type 3 muscarinic acetylcholine receptor generated during cytotoxic lymphocyte granule-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.197

Cutting Edge: Granzyme B Proteolysis of a Neuronal Glutamate Receptor Generates an Autoantigen and Is Modulated by Glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.197

Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.197

Altered immunogenicity of isoaspartate containing proteins.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2009.197

Autoimmunity and tumor immunity induced by immune responses to mutations in self

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2009.197

Selective cleavage of nucleolar autoantigen B23 by granzyme B in differentiated vascular smooth muscle cells: insights into the association of specific autoantibodies with distinct disease phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.197

Autoantibodies against B23, a nucleolar phosphoprotein, occur in scleroderma and are associated with pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.197

Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.197

T cell epitopes of the La/SSB autoantigen in humanized transgenic mice expressing the hLa class II haplotype DRB1*0301/DQB1*0201

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.197

Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.197

MMDB: Entrez's 3D-structure database.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.197

Contribution to antimitochondrial antibody production: cleavage of pyruvate dehydrogenase complex-E2 by apoptosis-related proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.197

The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.197

Antihemostatic Activity of Human Granzyme B Mediated by Cleavage of von Willebrand Factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.197

CD4 T-cell autoreactivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis

21 January 2018

1 reference

12 December 2020

Functional subsets of CD4 T cells in rheumatoid synovitis

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12 December 2020

Early-onset myasthenia gravis: a recurring T-cell epitope in the adult-specific acetylcholine receptor epsilon subunit presented by the susceptibility allele HLA-DR52a

1 reference

12 December 2020

The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA)

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12 December 2020

Isoaspartyl post-translational modification triggers autoimmune responses to self-proteins

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12 December 2020

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12 December 2020

Granzyme B mediates neurotoxicity through a G-protein-coupled receptor

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12 December 2020

Preferential localization of CD8+ alpha E beta 7+ T cells around acinar epithelial cells with apoptosis in patients with Sjögren's syndrome

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12 December 2020

Overlap syndromes in the context of shared autoimmunity

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12 December 2020

Candidate T cell epitopes of the human La/SSB autoantigen

1 reference

12 December 2020

Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients

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12 December 2020

Medullary breast carcinoma. A reevaluation of 95 cases of breast cancer with inflammatory stroma

1 reference

12 December 2020