Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation (Q24641992)

2

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James A Thomas

3

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Allison Landstrom

4

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Jonathan D Ashwell

Molecular and Cellular Biology

5

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language of work or name

English

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publication date

May 2008

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published in

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volume

28

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page(s)

3538-47

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issue

10

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cites work

NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation

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Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation

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Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation

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Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases

7 April 2017

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Toll-like receptor signalling

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Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol

7 April 2017

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Distinct molecular mechanism for initiating TRAF6 signalling

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IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

7 April 2017

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

7 April 2017

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IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK)

7 April 2017

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Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB

7 April 2017

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IRAK: a kinase associated with the interleukin-1 receptor

7 April 2017

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Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells

7 April 2017

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Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

7 April 2017

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TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

7 April 2017

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Pyogenic bacterial infections in humans with IRAK-4 deficiency

7 April 2017

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Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

7 April 2017

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X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling

7 April 2017

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

7 April 2017

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TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway

7 April 2017

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Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

7 April 2017

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Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase

7 April 2017

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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

7 April 2017

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TRAF6 is a signal transducer for interleukin-1

7 April 2017

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Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

7 April 2017

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MyD88, an adapter protein involved in interleukin-1 signaling

7 April 2017

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MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

7 April 2017

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Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

7 April 2017

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Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]

7 April 2017

1 reference

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MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

7 April 2017

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Biologic basis for interleukin-1 in disease

7 April 2017

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The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.

7 April 2017

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A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity

27 September 2017

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IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423148

Immunobiology of Toll-like receptors: emerging trends

27 September 2017

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Recognition and signaling by toll-like receptors.

27 September 2017

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X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production

27 September 2017

1 reference

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IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness

27 September 2017

1 reference

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Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members

27 September 2017

1 reference

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The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus

27 September 2017

1 reference

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The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense.

27 September 2017

1 reference

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Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423148

Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase

27 September 2017

1 reference

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Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity

27 September 2017

1 reference

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Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

27 September 2017

1 reference

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Dominant negative mutant of c-Jun inhibits NF-AT transcriptional activity and prevents IL-2 gene transcription

27 September 2017

1 reference

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Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423148

Essential function for the kinase TAK1 in innate and adaptive immune responses.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423148

NEMO/IKK gamma-deficient mice model incontinentia pigmenti.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423148

IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423148

Reprogramming the signalling requirement for AP-1 (activator protein-1) activation during differentiation of precursor CD4+ T-cells into effector Th1 and Th2 cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423148

Human T cell activation through the activation-inducer molecule/CD69 enhances the activity of transcription factor AP-1

28 November 2018

1 reference

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The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18347055

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18347055

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Toll-like receptors control activation of adaptive immune responses

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18347055