Investigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy (Q24644090)

1

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O M Dorchies

2

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O Patthey-Vuadens

3

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G Vuagniaux

British Journal of Pharmacology

4

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language of work or name

English

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publication date

October 2008

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published in

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volume

155

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page(s)

574-84

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issue

4

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cites work

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Primary role of functional ischemia, quantitative evidence for the two-hit mechanism, and phosphodiesterase-5 inhibitor therapy in mouse muscular dystrophy

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

7 April 2017

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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

7 April 2017

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Effect of cyclosporin A and its vehicle on cardiac and skeletal muscle mitochondria: relationship to efficacy of the respiratory chain

7 April 2017

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The mitochondrial permeability transition pore and its role in cell death

7 April 2017

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Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

7 April 2017

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Skeletal muscle fatigue: cellular mechanisms

27 September 2017

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New therapies for Duchenne muscular dystrophy: challenges, prospects and clinical trials.

27 September 2017

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Cyclophilin inhibitors in hepatitis C viral infection

27 September 2017

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Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis

27 September 2017

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Mitochondrial dysfunction in the pathogenesis of Ullrich congenital muscular dystrophy and prospective therapy with cyclosporins

27 September 2017

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The role of free radicals in the pathophysiology of muscular dystrophy

27 September 2017

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Mitochondrial oxidative stress: implications for cell death

27 September 2017

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Cyclosporine increases human immunodeficiency virus type 1 vector transduction of primary mouse cells.

27 September 2017

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The mitochondrial permeability transition from in vitro artifact to disease target

27 September 2017

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Mitochondrial permeability transition pore and postconditioning

27 September 2017

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Lipid peroxidation inhibition blunts nuclear factor-kappaB activation, reduces skeletal muscle degeneration, and enhances muscle function in mdx mice.

27 September 2017

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Mitochondria: pharmacological manipulation of cell death

27 September 2017

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Genetic dissection of the permeability transition pore

27 September 2017

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Molecular, cellular, and pharmacological therapies for Duchenne/Becker muscular dystrophies.

27 September 2017

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Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.

27 September 2017

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Prednisolone-induced changes in dystrophic skeletal muscle

27 September 2017

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A multidisciplinary evaluation of the effectiveness of cyclosporine a in dystrophic mdx mice.

27 September 2017

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STRESS signaling pathways that modulate cardiac myocyte apoptosis

27 September 2017

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Duchenne muscular dystrophy and dystrophin: pathogenesis and opportunities for treatment

27 September 2017

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The nonimmunosuppressive cyclosporin analogs NIM811 and UNIL025 display nanomolar potencies on permeability transition in brain-derived mitochondria.

27 September 2017

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Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs

27 September 2017

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Pharmacological strategies for muscular dystrophy

27 September 2017

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Calcium signaling and apoptosis

27 September 2017

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Cyclosporin A blocks muscle differentiation by inducing oxidative stress and inhibiting the peptidyl-prolyl-cis-trans isomerase activity of cyclophilin A: cyclophilin A protects myoblasts from cyclosporin A-induced cytotoxicity

27 September 2017

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Function and genetics of dystrophin and dystrophin-related proteins in muscle

27 September 2017

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A mitochondrial perspective on cell death

27 September 2017

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The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ

27 September 2017

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Calcium, calcineurin, and the control of transcription

27 September 2017

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Alteration in calcium handling at the subcellular level in mdx myotubes.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Calcineurin activity is required for the initiation of skeletal muscle differentiation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Mitochondrial transport of cations: channels, exchangers, and permeability transition.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Regulation of cytosolic calcium in skeletal muscle cells of the mdx mouse under conditions of stress

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Modulation by prednisolone of calcium handling in skeletal muscle cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Dystrophin protects the sarcolemma from stresses developed during muscle contraction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Pharmacology of cyclosporine (sandimmune). VII. Pathophysiology and toxicology of cyclosporine in humans and animals

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adeni

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Tumor necrosis factor-alpha up-regulates Bcl-2 expression and decreases calcium-dependent apoptosis in human B cell lines

27 September 2017

1 reference

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Caspase 3 expression correlates with skeletal muscle apoptosis in Duchenne and facioscapulo human muscular dystrophy. A potential target for pharmacological treatment?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Impaired mitochondrial oxidative phosphorylation in skeletal muscle of the dystrophin-deficient mdx mouse.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals.

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Apoptosis, DNA damage and ubiquitin expression in normal and mdx muscle fibers after exercise

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Conservation of the Duchenne muscular dystrophy gene in mice and humans

30 May 2018

1 reference

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Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization

30 May 2018

1 reference

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Visualization of dystrophic muscle fibers in mdx mouse by vital staining with Evans blue: evidence of apoptosis in dystrophin-deficient muscle.

30 May 2018

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Cyclosporine increases muscular force generation in Duchenne muscular dystrophy.

21 January 2018

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L-Carnitine: a potential treatment for blocking apoptosis and preventing skeletal muscle myopathy in heart failure

21 January 2018

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Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: beneficial effect of pentoxifylline.

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Green tea extract and its major polyphenol (-)-epigallocatechin gallate improve muscle function in a mouse model for Duchenne muscular dystrophy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Novel cell-penetrating alpha-keto-amide calpain inhibitors as potential treatment for muscular dystrophy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF-AT pathway.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Desensitization of the permeability transition pore by cyclosporin a prevents activation of the mitochondrial apoptotic pathway and liver damage by tumor necrosis factor-alpha

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

The calcineurin signal transduction pathway is essential for successful muscle regeneration in mdx dystrophic mice.

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Skeletal muscle metabolism in Duchenne muscular dystrophy (DMD): an in-vitro proton NMR spectroscopy study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Steroids in Duchenne muscular dystrophy: from clinical trials to genomic research

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Creatine supplementation reduces skeletal muscle degeneration and enhances mitochondrial function in mdx mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Purification of mouse primary myoblasts based on alpha 7 integrin expression.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Differential expression of dystrophin isoforms in strains of mdx mice with different mutations

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Apoptosis precedes necrosis of dystrophin-deficient muscle

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

The presence of two classes of high-affinity cyclosporin A binding sites in mitochondria. Evidence that the minor component is involved in the opening of an inner-membrane Ca(2+)-dependent pore.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2579666

Determination of the number of endothelial cells in culture using an acid phosphatase assay

28 November 2018

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12 December 2020

A qualitative and quantitative study of the ultrastructure of regenerating muscle fibres in Duchenne muscular dystrophy and polymyositis

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12 December 2020

Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss

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12 December 2020

Dystrophin deficient myotubes undergo apoptosis in mouse primary muscle cell culture after DNA damage

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12 December 2020

Creatine supplementation improves intracellular Ca2+ handling and survival in mdx skeletal muscle cells

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12 December 2020

Calcium content and respiratory control index of isolated skeletal muscle mitochondria: effects of different isolation media.

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12 December 2020

Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells

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12 December 2020

Mitochondria and apoptosis

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12 December 2020

Muscle cells from mdx mice have an increased susceptibility to oxidative stress

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12 December 2020

Activated calcineurin ameliorates contraction-induced injury to skeletal muscles of mdx dystrophic mice

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12 December 2020

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12 December 2020

Muscle-specific BCL2 expression ameliorates muscle disease in laminin {alpha}2-deficient, but not in dystrophin-deficient, mice

1 reference

12 December 2020

Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice

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12 December 2020

Overexpression of Bcl-2 suppresses the calcium activation of a mitochondrial megachannel

1 reference

12 December 2020

Mdx myotubes have normal excitability but show reduced contraction-relaxation dynamics

1 reference

12 December 2020

Green tea extract decreases muscle necrosis in mdx mice and protects against reactive oxygen species

1 reference

12 December 2020