Using the deadly mu-conotoxins as probes of voltage-gated sodium channels (Q24644685)

The voltage-sensitive sodium channel is a bell-shaped molecule with several cavities

Europe PubMed Central

title

Using the deadly mu-conotoxins as probes of voltage-gated sodium channels (English)

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Ronald A Li

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Gordon F Tomaselli

series ordinal

2

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language of work or name

English

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publication date

August 2004

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published in

Toxicon

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volume

44

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issue

2

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page(s)

117-22

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cites work

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The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

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Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels

7 April 2017

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Structure-activity relationships of mu-conotoxin GIIIA: structure determination of active and inactive sodium channel blocker peptides by NMR and simulated annealing calculations

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Nomenclature of voltage-gated sodium channels

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Novel Interactions Identified between μ-Conotoxin and the Na+ Channel Domain I P-loop: Implications for Toxin-Pore Binding Geometry

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Electrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin

27 September 2017

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Molecular architecture of the voltage-dependent Na channel: functional evidence for alpha helices in the pore

27 September 2017

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Clockwise domain arrangement of the sodium channel revealed by (mu)-conotoxin (GIIIA) docking orientation.

27 September 2017

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mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains

27 September 2017

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Conotoxins, in retrospect

27 September 2017

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Novel structural determinants of mu-conotoxin (GIIIB) block in rat skeletal muscle (mu1) Na+ channels

27 September 2017

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Charged residues between the selectivity filter and S6 segments contribute to the permeation phenotype of the sodium channel

27 September 2017

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Pore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis

27 September 2017

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Ion channels as enzymes: analogy or homology?

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Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms

27 September 2017

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Electrostatic distance geometry in a K+ channel vestibule

27 September 2017

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Discrimination of muscle and neuronal Na-channel subtypes by binding competition between [3H]saxitoxin and mu-conotoxins

27 September 2017

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A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties

27 September 2017

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Action of derivatives of mu-conotoxin GIIIA on sodium channels. Single amino acid substitutions in the toxin separately affect association and dissociation rates

30 May 2018

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Molecular localization of an ion-binding site within the pore of mammalian sodium channels

30 May 2018

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Dependence of mu-conotoxin block of sodium channels on ionic strength but not on the permeating [Na+]: implications for the distinctive mechanistic interactions between Na+ and K+ channel pore-blocking toxins and their molecular targets

30 May 2018

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Molecular basis of isoform-specific micro-conotoxin block of cardiac, skeletal muscle, and brain Na+ channels

28 November 2018

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Charge conversion enables quantification of the proximity between a normally-neutral mu-conotoxin (GIIIA) site and the Na+ channel pore

28 November 2018

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Latent specificity of molecular recognition in sodium channels engineered to discriminate between two "indistinguishable" mu-conotoxins

28 November 2018

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Pore-blocking toxins as probes of voltage-dependent channels.

28 November 2018

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Predominant interactions between mu-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysis

28 November 2018

1 reference

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Disulfide pairings in geographutoxin I, a peptide neurotoxin from Conus geographus

28 November 2018

1 reference

PubMed

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12 December 2020

inferred from PubMed ID database lookup

Depth asymmetries of the pore-lining segments of the Na+ channel revealed by cysteine mutagenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15246758

12 December 2020

inferred from PubMed ID database lookup

Active site of mu-conotoxin GIIIA, a peptide blocker of muscle sodium channels

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15246758

12 December 2020