Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis (Q24645884)

6

2

Emilyn U

Alejandro

1 reference

19 October 2023

Dan S Luciani

3

Dan S

Luciani

1 reference

19 October 2023

Tatyana B Kalynyak

4

Tatyana B

Kalynyak

1 reference

19 October 2023

Xiaoke Hu

5

Xiaoke

Hu

1 reference

19 October 2023

Hong Li

6

Hong

Li

1 reference

19 October 2023

Yalin Lin

7

Yalin

Lin

1 reference

19 October 2023

R Reid Townsend

8

R Reid

Townsend

1 reference

19 October 2023

Kenneth S Polonsky

9

Kenneth S

Polonsky

1 reference

19 October 2023

James D Johnson

10

James D

Proceedings of the National Academy of Sciences of the United States of America

Johnson

1 reference

19 October 2023

language of work or name

English

0 references

publication date

17 June 2008

0 references

published in

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volume

105

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issue

24

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page(s)

8452-7

0 references

cites work

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Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells

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Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

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Enkephalin convertase: purification and characterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenal chromaffin granules

7 April 2017

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Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

7 April 2017

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Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload

7 April 2017

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

7 April 2017

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Insulin gene mutations as a cause of permanent neonatal diabetes

7 April 2017

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Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

27 September 2017

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Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

27 September 2017

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ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity

27 September 2017

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Deficiency of ATP2C1, a Golgi ion pump, induces secretory pathway defects in endoplasmic reticulum (ER)-associated degradation and sensitivity to ER stress

27 September 2017

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Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

27 September 2017

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Chronic effects of fatty acids on pancreatic beta-cell function: new insights from functional genomics.

27 September 2017

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Palmitate-induced Ca2+-signaling in pancreatic beta-cells

27 September 2017

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Triglyceride accumulation protects against fatty acid-induced lipotoxicity

27 September 2017

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Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.

27 September 2017

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Endoplasmic reticulum stress and the development of diabetes: a review

27 September 2017

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Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells

27 September 2017

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Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity.

27 September 2017

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Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice.

27 September 2017

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Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic beta-cell line INS-1.

27 September 2017

1 reference

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Long-term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta-cell line MIN6.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity

27 September 2017

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Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1.

27 September 2017

1 reference

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Tissue distribution and characterization of soluble and membrane-bound forms of metallocarboxypeptidase D.

27 September 2017

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Fasting proinsulin and 2-h post-load glucose levels predict the conversion to NIDDM in subjects with impaired glucose tolerance: the Hoorn Study.

27 September 2017

1 reference

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Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

27 September 2017

1 reference

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Fatty acid distribution in systems modeling the normal and diabetic human circulation. A 13C nuclear magnetic resonance study.

27 September 2017

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Increases in serum unbound free fatty acid levels following coronary angioplasty

27 September 2017

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Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

Proinsulin levels predict the development of non-insulin-dependent diabetes mellitus (NIDDM) in Japanese-American men.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse beta-cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

Regulation of carboxypeptidase E. Effect of Ca2+ on enzyme activity and stability.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

Different role of saturated and unsaturated fatty acids in beta-cell apoptosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

Effects of free fatty acids on beta-cell functions: a possible involvement of peroxisome proliferator-activated receptors alpha or pancreatic/duodenal homeobox

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448857

A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse.

28 November 2018

1 reference

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Isolation and Characterization of Proinsulin C-Peptide from Bovine Pancreas

28 November 2018

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12 December 2020

Molecular Heterogeneity and Cellular Localization of Carboxypeptidase H in the Islets of Langerhans*

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12 December 2020

Interaction between perchlorate and nifedipine on insulin secretion from mouse pancreatic islets

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12 December 2020

Palmitate-induced beta-cell insensitivity to glucose is coupled to decreased pyruvate dehydrogenase activity and enhanced kinase activity in rat pancreatic islets

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Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans

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Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro

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12 December 2020