Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression (Q45078045)

9 December 2017

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression (English)

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9 December 2017

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7

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8

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9 December 2017

William I Sivitz

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author name string

Jamie W Joseph

1

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9 December 2017

Vasilij Koshkin

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Monique C Saleh

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Chen-Yu Zhang

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9 December 2017

Bradford B Lowell

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language of work or name

English

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publication date

23 September 2004

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Journal of Biological Chemistry

9 December 2017

8

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based on heuristic

inferred from page(s)

published in

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279

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9 December 2017

51049-51056

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9 December 2017

49

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Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.

9 December 2017

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https://api.crossref.org/works/10.1074%2FJBC.M409189200

Superoxide activates mitochondrial uncoupling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Uncoupling protein 2 promoter polymorphism -866G/A affects its expression in beta-cells and modulates clinical profiles of Japanese type 2 diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Cytokine-induced apoptosis and necrosis are preceded by disruption of the mitochondrial membrane potential (Deltapsi(m)) in pancreatic RINm5F cells: prevention by Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Exogenous nitric oxide and endogenous glucose-stimulated beta-cell nitric oxide augment insulin release

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

The rat glucagon gene is regulated by a protein kinase A-dependent pathway in pancreatic islet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Bioluminometric assay of ADP and ATP at high ATP/ADP ratios: assay of ADP after enzymatic removal of ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Tissue-specific differences in the levels of proglucagon-derived peptides in streptozotocin-induced diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Ca2+ oscillations in pancreatic islet cells secreting glucagon and somatostatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

Coenzyme Q is an obligatory cofactor for uncoupling protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409189200

21 January 2018

Identifiers

DOI

10.1074/JBC.M409189200

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9 December 2017

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