Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica (Q24646019)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19746976%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

title

Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19746976%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

0 references

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19746976%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Bradley S. Moore

5

1 reference

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7 February 2020

author name string

Markus Nett

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19746976%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Andrew J Kale

3

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7 February 2020

Chambers C Hughes

4

1 reference

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7 February 2020

language of work or name

English

0 references

publication date

1 October 2009

1 reference

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Journal of Medicinal Chemistry

7 February 2020

published in

1 reference

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7 February 2020

volume

52

1 reference

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7 February 2020

issue

19

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7 February 2020

page(s)

6163-6167

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Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry

7 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Catalytic mechanism and assembly of the proteasome.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Advances in and applications of proteasome inhibitors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Proteasome inhibitors in cancer therapy: lessons from the first decade

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Natural occurrence, syntheses, and applications of cyclopropyl-group-containing alpha-amino acids. 2. 3,4- and 4,5-methanoamino acids

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Proteasome inhibitors: poisons and remedies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Total synthesis of lactacystin and salinosporamide A.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

20S proteasome and its inhibitors: crystallographic knowledge for drug development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Syntheses and biological activities of some cycloalkenealanines.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Antiprotealide is a natural product.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Leaving groups prolong the duration of 20S proteasome inhibition and enhance the potency of salinosporamides

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Energetic differences between the five- and six-membered ring hydrocarbons: strain energies in the parent and radical molecules.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

An efficient, stereocontrolled synthesis of a potent omuralide-salinosporin hybrid for selective proteasome inhibition.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2771571

Proteolysis: from the lysosome to ubiquitin and the proteasome

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19746976

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Total synthesis and biological activity of lactacystin, omuralide and analogs

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19746976

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM901098M

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19746976%20AND%20SRC:MED&resulttype=core&format=json

release_d6ltl5jn5vcwfognxhzfmj54k4

7 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/d6ltl5jn5vcwfognxhzfmj54k4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19746976%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference