Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates (Q24646644)

28

0 references

Hans-Peter Vornlocher

27

Hans-Peter Vornlocher

0 references

Ingo Röhl

20

Ingo Röhl

0 references

Victor E. Koteliansky

31

Victor Koteliansky

0 references

Daniel G Anderson

29

Daniel G Anderson

0 references

Maria Frank-Kamenetsky

1

Maria Frank-Kamenetsky

0 references

Timothy S Racie

4

Timothy S Racie

0 references

Akin Akinc

6

Akin Akinc

0 references

J Robert Dorkin

9

Robert Dorkin

0 references

Christina Gamba-Vitalo

11

Christina Gamba-Vitalo

0 references

Philipp Hadwiger

12

Philipp Hadwiger

0 references

Muthusamy Jayaraman

13

K Narayanannair Jayaprakash

Muthusamy Jayaraman

0 references

15

K Narayanannair Jayaprakash

0 references

Lubomir Nechev

17

Kallanthottathil G Rajeev

Lubomir Nechev

0 references

18

Kallanthottathil G Rajeev

0 references

Jürgen Soutschek

21

Jürgen Soutschek

0 references

Tracy S Zimmermann

25

Tracy Zimmermann

0 references

Antonin de Fougerolles

26

Antonin de Fougerolles

0 references

Muthiah Manoharan

30

Muthiah Manoharan

0 references

Jay D Horton

32

Jay D Horton

0 references

author name string

Aldo Grefhorst

2

0 references

Norma N Anderson

3

0 references

Birgit Bramlage

5

0 references

David Butler

7

0 references

Klaus Charisse

8

0 references

Yupeng Fan

10

0 references

Matthias John

14

0 references

Martin Maier

16

0 references

Timothy Read

19

0 references

Pamela Tan

22

0 references

Jamie Wong

23

0 references

Gang Wang

24

0 references

Kevin Fitzgerald

Proceedings of the National Academy of Sciences of the United States of America

33

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language of work or name

English

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publication date

19 August 2008

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published in

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volume

105

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page(s)

11915-20

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issue

33

0 references

cites work

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Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

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Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

7 April 2017

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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

7 April 2017

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Molecular biology of PCSK9: its role in LDL metabolism

7 April 2017

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The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

7 April 2017

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Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance

7 April 2017

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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

7 April 2017

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Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice

7 April 2017

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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

7 April 2017

1 reference

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Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

7 April 2017

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A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

7 April 2017

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Plasma PCSK9 preferentially reduces liver LDL receptors in mice

27 September 2017

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Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

27 September 2017

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Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

27 September 2017

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siRNA and isRNA: two edges of one sword

27 September 2017

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Improved outcome after acute coronary syndromes with an intensive versus standard lipid-lowering regimen: results from the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) trial

27 September 2017

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Proprotein convertases: "master switches" in the regulation of tumor growth and progression

27 September 2017

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Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

27 September 2017

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Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

27 September 2017

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NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

27 September 2017

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Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial

27 September 2017

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Effect of lovastatin on the secretion of very low density lipoprotein lipids and apolipoprotein B in the hypertriglyceridemic Zucker obese rat.

27 September 2017

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Lipid-lowering activity of atorvastatin and lovastatin in rodent species: triglyceride-lowering in rats correlates with efficacy in LDL animal models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0805434105

Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0805434105

Effectiveness of ezetimibe alone or in combination with twice a week Atorvastatin (10 mg) for statin intolerant high-risk patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0805434105

RNAi-mediated gene silencing in non-human primates.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575310

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575310

28 November 2018

Identifiers

DOI

10.1073/PNAS.0805434105

1 reference

1857229

ADS bibcode

2008PNAS..10511915F

0 references

1857229

1 reference

1 reference

1 reference