Serotonergic drugs and valvular heart disease (Q24646869)

Expert Opinion on Drug Safety

Europe PubMed Central

title

Serotonergic drugs and valvular heart disease (English)

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1 reference

1

Richard B Rothman

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Michael H Baumann

series ordinal

2

object named as

Michael H Baumann

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language of work or name

English

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publication date

May 2009

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published in

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volume

8

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issue

3

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page(s)

317-29

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cites work

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Drugs and valvular heart disease

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Lisuride, a dopamine receptor agonist with 5-HT2B receptor antagonist properties: absence of cardiac valvulopathy adverse drug reaction reports supports the concept of a crucial role for 5-HT2B receptor agonism in cardiac valvular fibrosis

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3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro

7 April 2017

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Effect of fenfluramine-derivative diet pills on cardiac valves: a meta-analysis of observational studies

7 April 2017

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Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension

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Appetite suppressants and valvular heart disease

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Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications

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Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine

7 April 2017

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Aminorex to fen/phen: an epidemic foretold

7 April 2017

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Valvular heart disease associated with fenfluramine-phentermine

7 April 2017

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International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin)

7 April 2017

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Pharmacokinetics of methysergide and its metabolite methylergometrine in man

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5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis

7 April 2017

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Cardiac valvular pathology: comparative pathology and animal models of acquired cardiac valvular diseases

27 September 2017

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The dark side of ecstasy: neuropsychiatric symptoms after exposure to 3,4-methylenedioxymethamphetamine

27 September 2017

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Comparison of combinations of drugs for treatment of obesity: body weight and echocardiographic status.

27 September 2017

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Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'.

27 September 2017

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27 September 2017

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Long-term serotonin administration induces heart valve disease in rats.

27 September 2017

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Mouse genetic approaches to feeding regulation: serotonin 5-HT2C receptor mutant mice.

27 September 2017

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Therapeutic and adverse actions of serotonin transporter substrates

27 September 2017

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5-hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension

27 September 2017

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Chronic treatment with phentermine combined with fenfluramine lowers plasma serotonin.

27 September 2017

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Obesity drugs and the heart

27 September 2017

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Indan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential

27 September 2017

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Biological actions of drugs affecting serotonin and eating

27 September 2017

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Aortic and mitral valve disease induced by ergotamine therapy for migraine: a case report and review of the literature.

27 September 2017

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From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters

27 September 2017

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Stimulation of aortic smooth muscle cell mitogenesis by serotonin

27 September 2017

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Neurochemical mechanism of action of drugs which modify feeding via the serotoninergic system

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2695569

Appetite suppressants. A review

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2695569

Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2695569

Effect of some anorectic agents on the uptake and release of 5-hydroxytryptamine by blood platelets of rats

27 September 2017

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Serotonergic modulation of behaviour: a phylogenetic overview

27 September 2017

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Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats.

27 September 2017

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A population-based study of appetite-suppressant drugs and the risk of cardiac-valve regurgitation

30 May 2018

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Effects of various factors on steady state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine.

30 May 2018

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Cardiac murmurs and endocardial fibrosis associated with methysergide therapy

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2695569

Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a Gi-protein

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2695569

Simultaneous effects of p-chloroamphetamine, d-fenfluramine, and reserpine on free and stored 5-hydroxytryptamine in brain and blood

30 May 2018

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Effects of mazindol and d-fenfluramine of 5-hydroxytryptamine uptake, storage and metabolism in blood platelets

30 May 2018

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Clinical and echocardiographic follow-up of patients previously treated with dexfenfluramine or phentermine/fenfluramine

30 May 2018

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(+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters

21 January 2018

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Effects on serotonin in rat hypothalamus of D-fenfluramine, aminorex, phentermine and fluoxetine

21 January 2018

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Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension.

21 January 2018

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The effect of the anorectic agent, d-fenfluramine, and its primary metabolite, d-norfenfluramine, on intact human platelet serotonin uptake and efflux

21 January 2018

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https://api.crossref.org/works/10.1517%2F14740330902931524

Chronic fenfluramine administration increases plasma serotonin (5-hydroxytryptamine) to nontoxic levels.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14740330902931524

Serum concentrations of fluoxetine in the clinical treatment setting

21 January 2018

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Association between selective serotonin-reuptake inhibitor therapy and heart valve regurgitation

21 January 2018

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https://api.crossref.org/works/10.1517%2F14740330902931524

Effects of sibutramine on ventricular dimensions and heart valves in obese patients during weight reduction

21 January 2018

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https://api.crossref.org/works/10.1517%2F14740330902931524

1-(m-chlorophenyl)piperazine (mCPP) dissociates in vivo serotonin release from long-term serotonin depletion in rat brain

21 January 2018

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https://api.crossref.org/works/10.1517%2F14740330902931524

Lisuride, a Dopamine Receptor Agonist With 5-HT2B Receptor Antagonist Properties

21 January 2018

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https://api.crossref.org/works/10.1517%2F14740330902931524

Appetite Suppressants and Valvular Heart Disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F14740330902931524

Noradrenergic and dopaminergic effects of (+)-amphetamine-like stimulants in the baboon Papio anubis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14740330902931524

Profiling of tryptophan-related plasma indoles in patients with carcinoid tumors by automated, on-line, solid-phase extraction and HPLC with fluorescence detection.

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2695569

Effects of phentermine and fenfluramine on extracellular dopamine and serotonin in rat nucleus accumbens: therapeutic implications.

28 November 2018

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Amphetamine analogs increase plasma serotonin: implications for cardiac and pulmonary disease

28 November 2018

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12 December 2020

In vivo model of drug-induced valvular heart disease in rats: pergolide-induced valvular heart disease demonstrated with echocardiography and correlation with pathology

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12 December 2020

Mitogenic and secretory responses of human valve interstitial cells to vasoactive agents

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12 December 2020

Discriminating capacity of indole markers in the diagnosis of carcinoid tumors

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12 December 2020

Pharmacokinetics of fenfluramine and norfenfluramine in volunteers given D- and DL-fenfluramine for 15 days

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12 December 2020

Increased plasma free serotonin but unchanged platelet serotonin in bipolar patients treated chronically with lithium

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12 December 2020

Improved diagnosis of carcinoid tumors by measurement of platelet serotonin

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12 December 2020

Effects of acute and chronic treatment with fluvoxamine on extracellular and platelet serotonin in the blood of major depressive patients. Relationship to clinical improvement

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12 December 2020

Comparative biodisposition and metabolism of 14C-(+/-)-fenfluramine in mouse, rat, dog and man

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12 December 2020

Amphetamine derivatives interact with both plasma membrane and secretory vesicle biogenic amine transporters

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12 December 2020

Intravenous administration of the serotonin agonist m-chlorophenylpiperazine (mCPP) increases extracellular serotonin in the diencephalon of awake rats

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12 December 2020

Carcinoid heart disease. Correlation of high serotonin levels with valvular abnormalities detected by cardiac catheterization and echocardiography

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12 December 2020

Studies of four novel diphenylbutylpiperazinepyridyl derivatives on release and inhibition of reuptake of dopamine, serotonin and noradrenaline by rat brain in vitro

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12 December 2020

Plasma concentrations of trazodone and m-chlorophenylpiperazine at steady state can be predicted from those after an initial dose of trazodone

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12 December 2020

In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor

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12 December 2020

Effect of dexfenfluramine treatment in rats exposed to acute and chronic hypoxia

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12 December 2020

Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascades

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12 December 2020

Phentermine and other monoamine-oxidase inhibitors may increase plasma serotonin when given with fenfluramines

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12 December 2020

Reduced satiating effect of d -fenfluramine in serotonin 5-HT 2C receptor mutant mice

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12 December 2020