Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis (Q24646926)

22 June 2017

title

Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis (English)

1 reference

22 June 2017

0 references

1 reference

5

Ann Richmond

1 reference

22 June 2017

Jiqing Sai

1

1 reference

22 June 2017

Dayanidhi Raman

series ordinal

2

1 reference

22 June 2017

Yuxin Liu

series ordinal

3

1 reference

22 June 2017

John Wikswo

series ordinal

4

1 reference

22 June 2017

language of work or name

English

0 references

publication date

28 July 2008

1 reference

Journal of Biological Chemistry

22 June 2017

published in

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22 June 2017

volume

283

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22 June 2017

issue

39

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22 June 2017

page(s)

26538-26547

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DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis

22 June 2017

cites work

1 reference

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7 April 2017

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7 April 2017

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RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration

7 April 2017

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DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1

7 April 2017

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Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity

7 April 2017

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DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines

7 April 2017

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Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity

7 April 2017

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Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

7 April 2017

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Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases

7 April 2017

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Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis

7 April 2017

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27 September 2017

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Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium

27 September 2017

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The IL sequence in the LLKIL motif in CXCR2 is required for full ligand-induced activation of Erk, Akt, and chemotaxis in HL60 cells

27 September 2017

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Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase

27 September 2017

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A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis

30 May 2018

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30 May 2018

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Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils

30 May 2018

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Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils.

21 January 2018

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Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805611200

Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805611200

Mouse bone marrow contains large numbers of functionally competent neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805611200

PI3Kgamma is the dominant isoform involved in migratory responses of human T lymphocytes: effects of ex vivo maintenance and limitations of non-viral delivery of siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805611200

PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805611200

PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M805611200

Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805611200

PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805611200

Chemotaxis in the Absence of PIP3 Gradients

21 January 2018

1 reference

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Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

21 January 2018

1 reference

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G protein signaling events are activated at the leading edge of chemotactic cells

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18662984

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M805611200

1 reference

22 June 2017

0 references

1 reference