A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication (Q24647097)

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12 February 2020

title

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication (English)

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Mini-chromosome maintenance complex protein 7 YBR202W

12 February 2020

main subject

1 reference

MCM DNA helicase complex subunit MCM5 YLR274W

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MCM DNA helicase complex subunit MCM2 YBL023C

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MCM DNA helicase complex subunit MCM3 YEL032W

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MCM DNA helicase complex subunit MCM4 YPR019W

1 reference

author

Bruce William Stillman

8

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12 February 2020

Christian Speck

9

1 reference

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author name string

Cecile Evrin

1

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12 February 2020

Pippa Clarke

2

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12 February 2020

Juergen Zech

3

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12 February 2020

Rudi Lurz

4

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12 February 2020

Jingchuan Sun

5

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12 February 2020

Stefan Uhle

6

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12 February 2020

Huilin Li

7

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12 February 2020

language of work or name

English

0 references

publication date

12 November 2009

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

12 February 2020

published in

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volume

106

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issue

48

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page(s)

20240-20245

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Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

12 February 2020

cites work

1 reference

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ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.

7 April 2017

1 reference

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Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins

7 April 2017

1 reference

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The structure and function of MCM from archaeal M. Thermoautotrophicum

7 April 2017

1 reference

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The Mcm2-7 complex has in vitro helicase activity.

7 April 2017

1 reference

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Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro

7 April 2017

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GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

7 April 2017

1 reference

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Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture.

7 April 2017

1 reference

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Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase.

7 April 2017

1 reference

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The B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formation

7 April 2017

1 reference

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Uninterrupted MCM2-7 function required for DNA replication fork progression

7 April 2017

1 reference

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Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin

7 April 2017

1 reference

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Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787165

An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787165

Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787165

Origin recognition and the chromosome cycle

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787165

ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787165

Interactions between two catalytically distinct MCM subgroups are essential for coordinated ATP hydrolysis and DNA replication

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787165

Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787165

ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787165

Two steps in the assembly of complexes at yeast replication origins in vivo

7 April 2017

1 reference

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Unwinding the structure and function of the archaeal MCM helicase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787165

Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787165

On helicases and other motor proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787165

Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787165

Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787165

Cell cycle regulation of DNA replication.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787165

Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication

27 September 2017

1 reference

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Double hexamer disruption and biochemical activities of Methanobacterium thermoautotrophicum MCM.

27 September 2017

1 reference

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Pumps, paradoxes and ploughshares: mechanism of the MCM2-7 DNA helicase

27 September 2017

1 reference

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Eukaryotic MCM proteins: beyond replication initiation

27 September 2017

1 reference

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Large T antigen on the simian virus 40 origin of replication: a 3D snapshot prior to DNA replication

27 September 2017

1 reference

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A rotary pumping model for helicase function of MCM proteins at a distance from replication forks.

27 September 2017

1 reference

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Stepwise assembly of initiation proteins at budding yeast replication origins in vitro

27 September 2017

1 reference

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Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex.

27 September 2017

1 reference

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Assembly of a double hexameric helicase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787165

Stoichiometry of DnaA and DnaB protein in initiation at the Escherichia coli chromosomal origin

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787165

Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787165

Molecular substructure of a viral receptor-recognition protein. The gp17 tail-fiber of bacteriophage T7

28 November 2018

1 reference

12 December 2020

ATP-dependent assembly of double hexamers of SV40 T antigen at the viral origin of DNA replication

1 reference

12 December 2020

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome

1 reference

12 December 2020

Overexpression of multisubunit replication factors in yeast

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0911500106

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19910535%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

ADS bibcode

2009PNAS..10620240E

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19910535%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

19910535

2 references