Immunoglobulin class switch recombination is impaired in Atm-deficient mice (Q24647660)

9

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Herbert C. Morse

object named as

Herbert C Morse

7

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Richard J. Hodes

11

object named as

Richard J Hodes

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author name string

Joanne M Lumsden

1

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Thomas McCarty

2

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Lisa K Petiniot

3

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Rhuna Shen

4

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Carrolee Barlow

5

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Thomas A Wynn

6

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Patricia J Gearhart

8

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Edward E Max

Journal of Experimental Medicine

10

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language of work or name

English

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publication date

1 November 2004

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published in

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volume

200

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page(s)

1111-21

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issue

9

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cites work

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

7 April 2017

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

7 April 2017

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

7 April 2017

1 reference

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53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage

7 April 2017

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

7 April 2017

1 reference

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Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor

7 April 2017

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

7 April 2017

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AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

7 April 2017

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

7 April 2017

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Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies

7 April 2017

1 reference

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The many substrates and functions of ATM

7 April 2017

1 reference

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Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

7 April 2017

1 reference

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Genomic instability in mice lacking histone H2AX

7 April 2017

1 reference

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Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

7 April 2017

1 reference

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

7 April 2017

1 reference

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Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

7 April 2017

1 reference

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Atm-deficient mice: a paradigm of ataxia telangiectasia

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch

10 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Single-stranded DNA breaks adjacent to cytosines occur during Ig gene class switch recombination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Sensing of intermediates in V(D)J recombination by ATM.

27 September 2017

1 reference

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CHK2 kinase--a busy messenger.

27 September 2017

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Ataxia telangiectasia gene mutations in leukaemia and lymphoma

27 September 2017

1 reference

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Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1.

27 September 2017

1 reference

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ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

The controlling role of ATM in homologous recombinational repair of DNA damage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

ATM in lymphoid development and tumorigenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

ATM associates with and phosphorylates p53: mapping the region of interaction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Leukemia and lymphoma in ataxia telangiectasia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Disorders of B cells and helper T cells in the pathogenesis of the immunoglobulin deficiency of patients with ataxia telangiectasia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Characterization of the IgG response induced by polyclonal B cell activators

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Quantitation of immunoglobulin mu-gamma 1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Cell differentiation in the presence of cytochalasin B: studies on the "switch" to IgG secretion after polyclonal B cell activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Deficiencies in CD4+ and CD8+ T cell subsets in ataxia telangiectasia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Ku80 is required for immunoglobulin isotype switching

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Immunoglobulin E deficiency in ataxia-telangiectasia

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Cell cycle kinetics model of LPS-stimulated spleen cells correlates switch region rearrangements with S phase

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Membrane expression of IgG but not maturation to secretion requires DNA replication.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211853

Transcription-coupled events associating with immunoglobulin switch region chromatin

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20041074

Nuclear retention of ATM at sites of DNA double strand breaks

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20041074

Skewed T-cell receptor repertoire, decreased thymic output, and predominance of terminally differentiated T cells in ataxia telangiectasia.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20041074

Lymphoid tissue abnormalities associated with ataxia-telangiectasia

21 January 2018

1 reference

12 December 2020

Ataxia-telangiectasia

1 reference

12 December 2020

IgG2 deficiency in ataxia-telangiectasia

1 reference

12 December 2020

Heterogeneity of immunological abnormalities in ataxia-telangiectasia

1 reference

12 December 2020

Abnormal rearrangement within the alpha/delta T-cell receptor locus in lymphomas from Atm-deficient mice

1 reference

12 December 2020

Alternative end joining during switch recombination in patients with ataxia-telangiectasia

1 reference

12 December 2020

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

1 reference

12 December 2020

IgE class switching is critically dependent upon the nature of the B cell activator, in addition to the presence of IL-4

1 reference

12 December 2020

Regulation of human B cell function by recombinant CD40 ligand and other TNF-related ligands

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20041074

1 reference

1323087

1323087

1 reference

1 reference

1 reference