Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2 (Q28910215)

GOA release 2020-03-11

DNA mismatch repair

1 reference

Mismatch repair endonuclease PMS2

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

D. B. Winter

1

1 reference

7 March 2017

Q. H. Phung

2

1 reference

7 March 2017

A. Umar

3

1 reference

7 March 2017

S. M. Baker

4

1 reference

7 March 2017

R. E. Tarone

5

1 reference

7 March 2017

K. Tanaka

6

1 reference

7 March 2017

R. M. Liskay

7

1 reference

7 March 2017

T. A. Kunkel

8

1 reference

7 March 2017

V. A. Bohr

9

1 reference

7 March 2017

P. J. Gearhart

Proceedings of the National Academy of Sciences of the United States of America

10

1 reference

7 March 2017

language of work or name

English

0 references

publication date

9 June 1998

1 reference

7 March 2017

1 reference

7 March 2017

95

1 reference

7 March 2017

12

1 reference

7 March 2017

6953–6958

1 reference

7 March 2017

Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Biochemistry and genetics of eukaryotic mismatch repair

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Mismatch repair in replication fidelity, genetic recombination, and cancer biology

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

The transcriptional promoter regulates hypermutation of the antibody heavy chain locus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Relationships between DNA repair and transcription

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

DNA-replication fidelity, mismatch repair and genome instability in cancer cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Expressed human immunoglobulin kappa genes and their hypermutation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

A hPMS2 mutant cell line is defective in strand-specific mismatch repair

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Clusters of point mutations are found exclusively around rearranged antibody variable genes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Antibody diversity: somatic hypermutation of rearranged VH genes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Patterns of somatic mutations in immunoglobulin variable genes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Multiple point mutations in a shuttle vector propagated in human cells: evidence for an error-prone DNA polymerase activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Activation of memory and virgin B cell clones in hyperimmune animals.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune response

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

On the dependence of spontaneous mutation rates on the functional state of genes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Non-random features of the repertoire expressed by the members of one V kappa gene family and of the V-J recombination.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Mismatch repair co-opted by hypermutation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22699

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

26 November 2018

1 reference

12 December 2020

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1 reference

12 December 2020

Heteroduplex repair in extracts of human HeLa cells

1 reference

12 December 2020

Affinity maturation leads to differential expression of multiple copies of a κ light-chain transgene

1 reference

12 December 2020

MutY repair is mutagenic in mutT- strains of Escherichia coli

1 reference

12 December 2020

Somatic hypermutation of Ig genes in patients with xeroderma pigmentosum (XP-D)

1 reference

12 December 2020

The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes

1 reference

12 December 2020

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1 reference

12 December 2020