Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function (Q24648638)

2

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J Bubeck Wardenburg

3

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D Straus

4

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T Kurosaki

5

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A C Chan

Molecular and Cellular Biology

6

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language of work or name

English

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publication date

September 1996

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published in

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volume

16

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issue

9

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page(s)

5026-35

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cites work

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Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins

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Essential role for ZAP-70 in both positive and negative selection of thymocytes

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Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

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ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

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ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency

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Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70

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The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav

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Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

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Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

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28 September 2017

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28 September 2017

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Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase

30 May 2018

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Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70

28 November 2018

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The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium

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12 December 2020

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56 lck

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12 December 2020

A manual sequencing method for identification of phosphorylated amino acids in phosphopeptides

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12 December 2020

Tyrosine kinase-regulated and inositol phosphate-independent Ca2+ elevation and mobilization in T cells

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12 December 2020

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

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12 December 2020

Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase

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12 December 2020

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T Cells

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12 December 2020

Blocked Ras activation in anergic CD4+ T cells

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12 December 2020