G2E3 is a dual function ubiquitin ligase required for early embryonic development (Q24649733)

Ubiquitin-conjugating enzyme E2D 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

William S Brooks

1

0 references

E Scott Helton

2

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Sami Banerjee

3

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Melanie Venable

4

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Larry Johnson

5

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Trenton R Schoeb

6

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Robert A Kesterson

7

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David F Crawford

Journal of Biological Chemistry

8

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language of work or name

English

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publication date

8 August 2008

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published in

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volume

283

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issue

32

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page(s)

22304-15

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cites work

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Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events

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Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero

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A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

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cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript

7 April 2017

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Mouse emi1 has an essential function in mitotic progression during early embryogenesis

7 April 2017

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Failure to proliferate and mitotic arrest of CDK11(p110/p58)-null mutant mice at the blastocyst stage of embryonic cell development

7 April 2017

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The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2

7 April 2017

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Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response

7 April 2017

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The G(2) DNA damage checkpoint delays expression of genes encoding mitotic regulators

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ATR disruption leads to chromosomal fragmentation and early embryonic lethality

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Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

7 April 2017

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Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

7 April 2017

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7 April 2017

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Brca2 is required for embryonic cellular proliferation in the mouse

7 April 2017

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Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

7 April 2017

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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

7 April 2017

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Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

7 April 2017

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7 April 2017

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Identification of genes periodically expressed in the human cell cycle and their expression in tumors

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

Cell cycle regulation during early mouse embryogenesis.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis

28 September 2017

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Living with or without cyclins and cyclin-dependent kinases

28 September 2017

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Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion

28 September 2017

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AIRE functions as an E3 ubiquitin ligase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

The pineapple eye gene is required for survival of Drosophila imaginal disc cells.

28 September 2017

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The Fanconi road to cancer

28 September 2017

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Scores of RINGS but No PHDs in Ubiquitin Signaling

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

Development of mice expressing a single D-type cyclin.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

PHD domains and E3 ubiquitin ligases: viruses make the connection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

Analysis of cell-cycle-specific gene expression in human cells as determined by microarrays and double-thymidine block synchronization

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

NYD-SP6, a novel gene potentially involved in regulating testicular development/spermatogenesis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

The Pezcoller lecture: cancer cell cycles revisited

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

Microinjection of antibodies to centromere protein CENP-A arrests cells in interphase but does not prevent mitosis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

The genetic defect in ataxia-telangiectasia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

Morphological and biochemical characterization and analysis of apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

Delayed early embryonic lethality following disruption of the murine cyclin A2 gene.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494922

Inactivation of the ubiquitin conjugating enzyme UBE2Q2 causes a prophase arrest and enhanced apoptosis in response to microtubule inhibiting agents.

30 May 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803238200

The plant homeodomain fingers of fission yeast Msc1 exhibit E3 ubiquitin ligase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803238200

A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803238200

The -4 phenylalanine is required for substrate ubiquitination catalyzed by HECT ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803238200

Mouse development and cell proliferation in the absence of D-cyclins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803238200

c-MIR, a Human E3 Ubiquitin Ligase, Is a Functional Homolog of Herpesvirus Proteins MIR1 and MIR2 and Has Similar Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803238200

The U box is a modified RING finger — a common domain in ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803238200

Gene expression profiling of HeLa cells in G1 or G2 phases

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18511420

12 December 2020

inferred from PubMed ID database lookup

No evidence for PHD fingers as ubiquitin ligases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18511420

12 December 2020

inferred from PubMed ID database lookup

Role of Bmi1 in H2A ubiquitylation and Hox gene silencing

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18511420

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M803238200

0 references

Fatcat ID

release_y44qq4tb6nchbbbajdgt2ehjai

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/y44qq4tb6nchbbbajdgt2ehjai

24 November 2022