BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models (Q24649935)

2

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T Shimamura

3

0 references

S Kubo

4

0 references

M Takahashi

5

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L R Chirieac

6

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R F Padera

7

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G I Shapiro

8

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A Baum

9

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F Himmelsbach

10

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W J Rettig

11

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M Meyerson

12

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F Solca

13

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H Greulich

14

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K-K Wong

A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours

15

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language of work or name

English

0 references

publication date

7 August 2008

0 references

published in

Oncogene

0 references

volume

27

0 references

page(s)

4702-11

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issue

34

0 references

cites work

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Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

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EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

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7 April 2017

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Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

7 April 2017

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Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy

7 April 2017

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EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity

28 September 2017

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Salvage therapy in patients with advanced non-small cell lung cancer

28 September 2017

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Therapeutic anti-EGFR antibody 806 generates responses in murine de novo EGFR mutant-dependent lung carcinomas

28 September 2017

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28 September 2017

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Pharmacology and signaling properties of epidermal growth factor receptor isoforms studied by bioluminescence resonance energy transfer

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Non-small-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272.

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An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor.

28 September 2017

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28 September 2017

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Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib

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Inhibition of tumor growth by poly(ethylene glycol) derivatives of anti-ErbB2 antibodies

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Allele-dependent variation in the relative cellular potency of distinct EGFR inhibitors

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Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18408761

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2008.109

1 reference

Dimensions Publication ID

63162

1025699363

0 references

63162

1 reference

1 reference

1 reference