MEKK3 initiates transforming growth factor beta 2-dependent epithelial-to-mesenchymal transition during endocardial cushion morphogenesis (Q24650601)

2

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Patti Parker

3

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Elisa Rogowitz

4

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Richard R Vaillancourt

5

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Todd D Camenisch

Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation

6

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language of work or name

English

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publication date

5 December 2008

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published in

Circulation Research

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volume

103

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issue

12

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page(s)

1430-40

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cites work

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Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

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Double-outlet right ventricle and overriding tricuspid valve reflect disturbances of looping, myocardialization, endocardial cushion differentiation, and apoptosis in TGF-beta(2)-knockout mice

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Mekk3 is essential for early embryonic cardiovascular development

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Periostin regulates atrioventricular valve maturation.

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BMP-2 induces cell migration and periostin expression during atrioventricular valvulogenesis

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Periostin promotes atrioventricular mesenchyme matrix invasion and remodeling mediated by integrin signaling through Rho/PI 3-kinase

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Bmp2 instructs cardiac progenitors to form the heart-valve-inducing field

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Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3

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Transforming growth factor beta signaling via Ras in mesenchymal cells requires p21-activated kinase 2 for extracellular signal-regulated kinase-dependent transcriptional responses

28 September 2017

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Temporal and distinct TGFbeta ligand requirements during mouse and avian endocardial cushion morphogenesis.

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Structural development of endocardial cushions

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The spectrum of cardiac anomalies in Noonan syndrome as a result of mutations in the PTPN11 gene

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MEKK4 regulates developmental EMT in the embryonic heart.

28 November 2018

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The essential role of MEKK3 signaling in angiotensin II-induced calcineurin/nuclear factor of activated T-cells activation

28 November 2018

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Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation

28 November 2018

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Identification and detection of the periostin gene in cardiac development.

28 November 2018

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Expression patterns of Tgfbeta1-3 associate with myocardialisation of the outflow tract and the development of the epicardium and the fibrous heart skeleton.

28 November 2018

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Slug is an essential target of TGFbeta2 signaling in the developing chicken heart.

28 November 2018

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Bone morphogenetic protein-2 acts synergistically with transforming growth factor-beta3 during endothelial-mesenchymal transformation in the developing chick heart.

28 November 2018

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TGFbeta2 and TGFbeta3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart.

28 November 2018

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MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis

28 November 2018

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12 December 2020

Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis

1 reference

12 December 2020

Expression of the intermediate filament vimentin and fibrillar proteins of the extracellular matrix related to embryonal heart development

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12 December 2020

Retinoblastoma protein interacts with ATF2 and JNK/p38 in stimulating the transforming growth factor-beta2 promoter

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12 December 2020

Invasion of mesenchyme into three-dimensional collagen gels: a regional and temporal analysis of interaction in embryonic heart tissue

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12 December 2020

Epithelial-mesenchymal cell transformation in the embryonic heart can be mediated, in part, by transforming growth factor beta

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12 December 2020

Neurofibromin modulation of ras activity is required for normal endocardial-mesenchymal transformation in the developing heart

1 reference

12 December 2020