Autophagy suppresses tumorigenesis through elimination of p62 (Q24650670)

1

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Cristina M Karp

2

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Brian Beaudoin

3

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Nhan Vuong

4

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Guanghua Chen

5

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Hsin-Yi Chen

6

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Kevin Bray

7

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Anupama Reddy

8

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Gyan Bhanot

9

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Celine Gelinas

10

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Robert S Dipaola

11

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Vassiliki Karantza-Wadsworth

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

12

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language of work or name

English

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publication date

12 June 2009

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published in

Cell

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volume

137

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page(s)

1062-75

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issue

6

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cites work

1 reference

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

7 April 2017

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Selective degradation of mitochondria by mitophagy

7 April 2017

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Hypoxia and defective apoptosis drive genomic instability and tumorigenesis

7 April 2017

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Oxidative protein folding in eukaryotes: mechanisms and consequences

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

7 April 2017

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

7 April 2017

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Autophagy in the Pathogenesis of Disease

7 April 2017

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

7 April 2017

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

7 April 2017

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Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins

7 April 2017

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7 April 2017

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Bax and Bak independently promote cytochrome C release from mitochondria

7 April 2017

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ORP150 protects against hypoxia/ischemia-induced neuronal death

7 April 2017

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Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

7 April 2017

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Growth factor regulation of autophagy and cell survival in the absence of apoptosis

7 April 2017

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The role of autophagy during the early neonatal starvation period

7 April 2017

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Role of autophagy in cancer

7 April 2017

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Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

7 April 2017

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Immortalized mouse epithelial cell models to study the role of apoptosis in cancer

7 April 2017

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The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis

28 September 2017

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Tumor suppression by autophagy through the management of metabolic stress

28 September 2017

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An oncogene-induced DNA damage model for cancer development

28 September 2017

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Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability

28 September 2017

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Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis

28 September 2017

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From Mallory to Mallory-Denk bodies: what, how and why?

28 September 2017

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Autophagy suppresses tumor progression by limiting chromosomal instability

28 September 2017

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Signal integration and diversification through the p62 scaffold protein

28 September 2017

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Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response

28 September 2017

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Protein disulfide isomerase expression is related to the invasive properties of malignant glioma

28 September 2017

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Role of autophagy in cancer: management of metabolic stress

28 September 2017

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28 September 2017

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Replication protein A and gamma-H2AX foci assembly is triggered by cellular response to DNA double-strand breaks

28 September 2017

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Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.

28 September 2017

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IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

30 May 2018

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Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma

28 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/19524509

12 December 2020

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Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma

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PubMed

https://pubmed.ncbi.nlm.nih.gov/19524509

12 December 2020

inferred from PubMed ID database lookup

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12 December 2020

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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

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https://api.crossref.org/works/10.1016%2FJ.CELL.2009.03.048

7 January 2021

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2009.03.048

7 January 2021

Quantitative noise analysis for gene expression microarray experiments

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7 January 2021

Relationship of gene expression and chromosomal abnormalities in colorectal cancer

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7 January 2021

10.1016/J.CELL.2009.03.048

Identifiers

DOI

1 reference

564543

564543

1 reference

1 reference

1 reference