Validation of TPX2 as a potential therapeutic target in pancreatic cancer cells. (Q24650802)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19861455%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Validation of TPX2 as a potential therapeutic target in pancreatic cancer cells (English)

1 reference

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11 February 2020

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6

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11 February 2020

author name string

Steven L Warner

1

1 reference

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11 February 2020

Bret J Stephens

2

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11 February 2020

Stanley Nwokenkwo

3

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11 February 2020

Galen Hostetter

4

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11 February 2020

Anastasia Sugeng

5

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11 February 2020

Jeffery M Trent

7

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11 February 2020

Haiyong Han

8

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11 February 2020

Daniel D Von Hoff

9

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11 February 2020

language of work or name

English

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publication date

27 October 2009

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11 February 2020

published in

Clinical Cancer Research

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11 February 2020

volume

15

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11 February 2020

issue

21

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11 February 2020

page(s)

6519-6528

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describes a project that uses

11 February 2020

ImageQuant

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

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The mechanism of spindle assembly: functions of Ran and its target TPX2

7 April 2017

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Human TPX2 is required for targeting Aurora-A kinase to the spindle

7 April 2017

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Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining

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Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells

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Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays

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Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen.

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Identification of genetic alterations in pancreatic cancer by the combined use of tissue microdissection and array-based comparative genomic hybridisation.

28 September 2017

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Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells

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AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer

28 September 2017

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Genome-wide aberrations in pancreatic adenocarcinoma.

28 September 2017

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RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.

28 September 2017

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High-resolution characterization of the pancreatic adenocarcinoma genome

28 September 2017

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Identification of human polo-like kinase 1 as a potential therapeutic target in pancreatic cancer

28 September 2017

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Immortal human pancreatic duct epithelial cell lines with near normal genotype and phenotype

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Quantitative RT-PCR: pitfalls and potential

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Chromosome 20q amplification regulates in vitro response to Kinesin-5 inhibitor.

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20q11.1 amplification in giant-cell tumor of bone: Array CGH, FISH, and association with outcome.

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Determinants for Aurora-A activation and Aurora-B discrimination by TPX2.

28 November 2018

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Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity.

28 November 2018

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An in vivo platform for translational drug development in pancreatic cancer

28 November 2018

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12 December 2020

Frequent gain of copy number on the long arm of chromosome 20 in human pancreatic adenocarcinoma

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12 December 2020

A novel mechanism for activation of the protein kinase Aurora A

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12 December 2020

Binding of TPX2 to Aurora A alters substrate and inhibitor interactions

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12 December 2020

10.1158/1078-0432.CCR-09-0077

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19861455%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19861455%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference