The mechanism of spindle assembly: functions of Ran and its target TPX2 (Q24678114)

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Contribution of noncentrosomal microtubules to spindle assembly in Drosophila spermatocytes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Structural basis of Aurora-A activation by TPX2 at the mitotic spindle

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

The human chromokinesin Kid is a plus end-directed microtubule-based motor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Human TPX2 is required for targeting Aurora-A kinase to the spindle

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

TPX2, A novel xenopus MAP involved in spindle pole organization

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Transport between the cell nucleus and the cytoplasm

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Nucleocytoplasmic transport: the soluble phase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Mitotic kinases as regulators of cell division and its checkpoints

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Xkid, a chromokinesin required for chromosome alignment on the metaphase plate

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Mitotic spindle organization by a plus-end-directed microtubule motor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Mitotic functions of the Ran GTPase network: the importance of being in the right place at the right time

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Importin alpha/beta and Ran-GTP regulate XCTK2 microtubule binding through a bipartite nuclear localization signal

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

The Ran GTPase regulates kinetochore function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

The small GTPase Ran: interpreting the signs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Importin alpha-regulated nucleation of microtubules by TPX2.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

The Ran GTPase: theme and variations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Separating centrosomes interact in the absence of associated chromosomes during mitosis in cultured vertebrate cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Roles of Ran-GTP and Ran-GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Role of importin-beta in coupling Ran to downstream targets in microtubule assembly

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Importin beta is a mitotic target of the small GTPase Ran in spindle assembly

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

The Ran-GTPase and cell-cycle control

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Centrosome-independent mitotic spindle formation in vertebrates

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

XCTK2: a kinesin-related protein that promotes mitotic spindle assembly in Xenopus laevis egg extracts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

The impact of chromosomes and centrosomes on spindle assembly as observed in living cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Chromosomal control of meiotic cell division.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Respective roles of centrosomes and chromatin in the conversion of microtubule arrays from interphase to metaphase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

Visualizing the spindle checkpoint in Drosophila spermatocytes.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo.

30 May 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200312112

Ran binds to chromatin by two distinct mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200312112

Bipolar meiotic spindle formation without chromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200312112

Determining the position of the cell division plane

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200312112

Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200312112

The Xenopus laevis aurora/Ip11p-related kinase pEg2 participates in the stability of the bipolar mitotic spindle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200312112

Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200312112

GTP hydrolysis by Ran is required for nuclear envelope assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200312112

Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200312112

Computer simulations reveal motor properties generating stable antiparallel microtubule interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200312112

Ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200312112

A role for Ran-GTP and Crm1 in blocking re-replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200312112

Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172015

A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly

28 November 2018

1 reference

12 December 2020

A novel mechanism for activation of the protein kinase Aurora A

1 reference

12 December 2020

The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5

1 reference

12 December 2020

Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran

1 reference

12 December 2020

Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation

1 reference

12 December 2020

Regulation ofXenopusAurora A Activation by TPX2

1 reference

12 December 2020

Identifiers

DOI

10.1083/JCB.200312112

1 reference

1 reference

1 reference

PubMed publication ID

15452138

1 reference