Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia (Q24657127)

1

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Marlene Buchebner

2

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Thomas Pfeifer

3

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Tatjana M Becker

4

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Georg Uray

5

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Makoto Miyazaki

6

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Shinobu Miyazaki-Anzai

7

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Birgit Ebner

8

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Prakash G Chandak

9

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Rajendra S Kadam

10

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Emine Calayir

11

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Nora Rathke

12

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Helmut Ahammer

13

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Branislav Radovic

14

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Gerald Hoefler

16

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Uday B Kompella

17

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Guenter Fauler

18

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Moshe Levi

19

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Sanja Levak-Frank

20

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Gerhard M Kostner

21

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Dagmar Kratky

Journal of Lipid Research

22

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language of work or name

English

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publication date

February 2009

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published in

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volume

50

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issue

2

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page(s)

312-26

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cites work

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Synthetic LXR ligand inhibits the development of atherosclerosis in mice

7 April 2017

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Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption

7 April 2017

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Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

7 April 2017

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Role of LXRs in control of lipogenesis

7 April 2017

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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

7 April 2017

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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

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ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport

7 April 2017

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Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

7 April 2017

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7 April 2017

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Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE

7 April 2017

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The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR

7 April 2017

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Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors

7 April 2017

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ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins

7 April 2017

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Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols

7 April 2017

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An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

7 April 2017

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A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver

7 April 2017

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7 April 2017

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Zetia: inhibition of Niemann-Pick C1 Like 1 (NPC1L1) to reduce intestinal cholesterol absorption and treat hyperlipidemia

7 April 2017

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Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation

28 September 2017

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Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis

28 September 2017

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A 15-ketosterol is a liver X receptor ligand that suppresses sterol-responsive element binding protein-2 activity.

28 September 2017

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Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor

28 September 2017

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LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells

28 September 2017

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Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

28 September 2017

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Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta.

28 September 2017

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The role of orphan nuclear receptors in the regulation of cholesterol homeostasis

28 September 2017

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ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR.

28 September 2017

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ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages

28 September 2017

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Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor

28 September 2017

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Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2,3-diacylglycerol

28 September 2017

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Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels.

30 May 2018

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Crossref

https://api.crossref.org/works/10.1194%2FJLR.M800376-JLR200

T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice

21 January 2018

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Niemann-Pick C1-like 1 is required for an LXR agonist to raise plasma HDL cholesterol in mice

21 January 2018

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Crossref

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Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18812595

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18812595