The promises and pitfalls of RNA-interference-based therapeutics (Q24657247)

The impact of microRNAs on protein output

Europe PubMed Central

title

The promises and pitfalls of RNA-interference-based therapeutics (English)

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1 reference

Daniela Castanotto

1

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John J Rossi

series ordinal

2

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language of work or name

English

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publication date

22 January 2009

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published in

Nature

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volume

457

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issue

7228

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page(s)

426-33

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cites work

1 reference

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Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

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RNAi-mediated targeting of heterochromatin by the RITS complex

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The response of mammalian cells to double-stranded RNA

7 April 2017

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Widespread changes in protein synthesis induced by microRNAs

7 April 2017

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

7 April 2017

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Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

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Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells

7 April 2017

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Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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RNAi-mediated pathways in the nucleus

7 April 2017

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Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

7 April 2017

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Control of stress-dependent cardiac growth and gene expression by a microRNA

7 April 2017

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RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

7 April 2017

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The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race

7 April 2017

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Expression profiling reveals off-target gene regulation by RNAi

7 April 2017

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MicroRNA-directed transcriptional gene silencing in mammalian cells

7 April 2017

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PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans

28 September 2017

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Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline

28 September 2017

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Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells.

28 September 2017

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Does the understanding of immune activation by RNA predict the design of safe siRNAs?

28 September 2017

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Small interfering RNAs induce macrophage migration inhibitory factor production and proliferation in breast cancer cells via a double-stranded RNA-dependent protein kinase-dependent mechanism.

28 September 2017

1 reference

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Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells

28 September 2017

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The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs

28 September 2017

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A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

28 September 2017

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Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

28 September 2017

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Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.

28 September 2017

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Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

28 September 2017

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MicroRNAs in disease and potential therapeutic applications

28 September 2017

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Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging

28 September 2017

1 reference

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Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC

28 September 2017

1 reference

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Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes

28 September 2017

1 reference

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Transvascular delivery of small interfering RNA to the central nervous system.

28 September 2017

1 reference

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Therapeutic potential for microRNAs

28 September 2017

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RNAi silencing in mouse models of neurodegenerative diseases

28 September 2017

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shRNA and siRNA delivery to the brain

28 September 2017

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Predicting siRNA efficiency

28 September 2017

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Rational design and in vitro and in vivo delivery of Dicer substrate siRNA.

28 September 2017

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28 September 2017

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2'-fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity.

28 September 2017

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Slicer and the argonautes

28 September 2017

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MicroRNA-cancer connection: the beginning of a new tale

28 September 2017

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siRNA and isRNA: two edges of one sword

28 September 2017

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Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

28 September 2017

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28 September 2017

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Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

28 September 2017

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3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

28 September 2017

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28 September 2017

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Attenuation of alpha2A-adrenergic receptor expression in neonatal rat brain by RNA interference or antisense oligonucleotide reduced anxiety in adulthood

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Small interfering RNA-induced transcriptional gene silencing in human cells

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siRNA relieves chronic neuropathic pain

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Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

28 September 2017

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RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system.

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28 November 2018

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28 November 2018

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28 November 2018

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28 November 2018

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28 November 2018

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28 November 2018

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28 November 2018

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28 November 2018

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28 November 2018

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28 November 2018

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28 November 2018

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28 November 2018

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RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

28 November 2018

1 reference

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RNAi in human cells: basic structural and functional features of small interfering RNA.

28 November 2018

1 reference

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Stable suppression of tumorigenicity by virus-mediated RNA interference

28 November 2018

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RNA interference in adult mice.

28 November 2018

1 reference

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RNA interference targeting Fas protects mice from fulminant hepatitis

28 November 2018

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12 December 2020

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

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12 December 2020

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

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12 December 2020

2'-O-methyl-modified RNAs act as TLR7 antagonists

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE07758

1 reference

Dimensions Publication ID

1254943

1021098775

0 references

1254943

1 reference

1 reference

1 reference