RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. (Q44964949)

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30 December 2019

title

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia (English)

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Harry T. Orr

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author name string

Haibin Xia

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Steven L Eliason

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Scott Q Harper

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Inês H Martins

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Henry L Paulson

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Linda Yang

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Robert M Kotin

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Beverly L Davidson

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language of work or name

English

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publication date

4 July 2004

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30 December 2019

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volume

10

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issue

8

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page(s)

816-820

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https://scigraph.springernature.com/pub.10.1038/nm1076

30 December 2019

exact match

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cites work

Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1.

1 reference

7 January 2021

Spinocerebellar ataxia type 1

1 reference

7 January 2021

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

1 reference

7 January 2021

Identification of genes that modify ataxin-1-induced neurodegeneration.

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7 January 2021

SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat

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7 January 2021

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

1 reference

7 January 2021

Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice

1 reference

7 January 2021

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

1 reference

7 January 2021

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

1 reference

7 January 2021

Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference

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7 January 2021

Allele-specific silencing of dominant disease genes

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7 January 2021

siRNA-mediated gene silencing in vitro and in vivo.

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7 January 2021

Molecular medicine for the brain: silencing of disease genes with RNA interference

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7 January 2021

A system for characterizing cellular and molecular events in programmed neuronal cell death.

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7 January 2021

Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells

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7 January 2021

Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations.

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7 January 2021

Transduction of murine cerebellar neurons with recombinant FIV and AAV5 vectors

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7 January 2021

Intranuclear ataxin1 inclusions contain both fast- and slow-exchanging components

1 reference

7 January 2021

Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis.

1 reference

7 January 2021

Rational siRNA design for RNA interference

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7 January 2021

Insect cells as a factory to produce adeno-associated virus type 2 vectors

1 reference

7 January 2021

U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells.

1 reference

7 January 2021

Three-dimensional counting: an accurate and direct method to estimate numbers of cells in sectioned material

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM1076

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30 December 2019

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