Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p (Q24657415)

1

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Jana Narasimhan

2

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Li Jiang

3

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Sheree A Wek

4

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Kimberly A Dittmar

5

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Tao Pan

7

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Ronald C Wek

Journal of Biological Chemistry

8

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language of work or name

English

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publication date

11 September 2009

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published in

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volume

284

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issue

37

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page(s)

25254-67

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cites work

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

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Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

7 April 2017

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Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain

7 April 2017

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Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

7 April 2017

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Tissue-specific differences in human transfer RNA expression

7 April 2017

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The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores

7 April 2017

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Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

7 April 2017

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

7 April 2017

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Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses

7 April 2017

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Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2

7 April 2017

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Gene-specific regulation by general translation factors

7 April 2017

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

7 April 2017

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Coping with stress: eIF2 kinases and translational control

7 April 2017

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Translational regulation of GCN4 and the general amino acid control of yeast

7 April 2017

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Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast

7 April 2017

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Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells

7 April 2017

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Translational control of long-lasting synaptic plasticity and memory

28 September 2017

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Dissection of the structural organization of the aminoacyl-tRNA synthetase complex

28 September 2017

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A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2.

28 September 2017

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Gcn4 is required for the response to peroxide stress in the yeast Saccharomyces cerevisiae.

28 September 2017

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Translational control and the unfolded protein response

28 September 2017

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eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory

28 September 2017

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Global translational responses to oxidative stress impact upon multiple levels of protein synthesis.

28 September 2017

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Selective charging of tRNA isoacceptors induced by amino-acid starvation

28 September 2017

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Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

28 September 2017

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Aminoacyl-tRNA synthetase complexes: beyond translation

28 September 2017

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Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

28 September 2017

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A domain for editing by an archaebacterial tRNA synthetase

28 September 2017

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Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.

28 September 2017

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Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress

28 September 2017

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The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice

28 September 2017

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Volatile anesthetics affect nutrient availability in yeast

28 September 2017

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Mutations that bypass tRNA binding activate the intrinsically defective kinase domain in GCN2.

28 September 2017

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Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses

28 September 2017

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The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757228

Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757228

In Saccharomyces cerevisae, feedback inhibition of homocitrate synthase isoenzymes by lysine modulates the activation of LYS gene expression by Lys14p

28 September 2017

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Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757228

Direct analysis of aminoacylation levels of tRNAs in vivo. Application to studying recognition of Escherichia coli initiator tRNA mutants by glutaminyl-tRNA synthetase

28 September 2017

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The protein kinase Gcn2p mediates sodium toxicity in yeast

19 June 2018

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https://api.crossref.org/works/10.1074%2FJBC.M109.000877

Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions

21 January 2018

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Cys-tRNA(Pro) editing by Haemophilus influenzae YbaK via a novel synthetase.YbaK.tRNA ternary complex

21 January 2018

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Trans-editing of Cys-tRNAPro by Haemophilus influenzae YbaK protein

21 January 2018

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Natural homolog of tRNA synthetase editing domain rescues conditional lethality caused by mistranslation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M109.000877

Transient inhibition of translation initiation by osmotic stress

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M109.000877

Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.000877

The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.000877

Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M109.000877

Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M109.000877

GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.

21 January 2018

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Exploring the regulation of tRNA distribution on the genomic scale

21 January 2018

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PubMed

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulation of compartmentation of amino acid pools in Saccharomyces cerevisiae and its effects on metabolic control

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19546227

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Seven mammalian aminoacyl-tRNA synthetases associated within the same complex are functionally independent

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19546227