Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain (Q27936337)

PubMed

1 December 2016

title

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain (English)

1 reference

PubMed

Serine/threonine-protein kinase GCN2 YDR283C

1 December 2016

main subject

1 reference

GOA release 2020-03-11

author name string

J Dong

1

0 references

H Qiu

2

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M Garcia-Barrio

3

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J Anderson

4

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A G Hinnebusch

5

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language of work or name

English

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publication date

August 2000

0 references

1 reference

Characterization of the hemin-sensitive eukaryotic initiation factor 2alpha kinase from mouse nonerythroid cells

1 December 2016

volume

6

0 references

issue

2

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page(s)

269-79

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cites work

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tRNA discrimination at the binding step by a class II aminoacyl-tRNA synthetase

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Translation initiation: adept at adapting

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Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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Aminoacyl-transfer RNA populations in mammalian cells. Chromatographic profiles and patterns of codon recognition

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Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.

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Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain

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7 January 2021

Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae

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7 January 2021

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases

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Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

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Class II aminoacyl transfer RNA synthetases: crystal structure of yeast aspartyl-tRNA synthetase complexed with tRNA(Asp)

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Cloning and characterization of a cDNA encoding a protein synthesis initiation factor-2alpha (eIF-2alpha) kinase from Drosophila melanogaster. Homology To yeast GCN2 protein kinase

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cpc-3, the Neurospora crassa homologue of yeast GCN2, encodes a polypeptide with juxtaposed eIF2alpha kinase and histidyl-tRNA synthetase-related domains required for general amino acid control

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Aminoacyl-tRNA Synthetases: General Features and Recognition of Transfer RNAs

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Functional characterization of the RNA-binding domain and motif of the double-stranded RNA-dependent protein kinase DAI (PKR).

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Escherichia coli formylmethionine tRNA: mutations in GGGCCC sequence conserved in anticodon stem of initiator tRNAs affect initiation of protein synthesis and conformation of anticodon loop

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Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

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Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability

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Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression

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7 January 2021

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

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Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

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Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control

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7 January 2021

10.1016/S1097-2765(00)00028-9

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017