Sox2 and Oct-3/4: a versatile pair of master regulators that orchestrate the self-renewal and pluripotency of embryonic stem cells (Q24657573)

Europe PubMed Central

title

Sox2 and Oct-3/4: a versatile pair of master regulators that orchestrate the self-renewal and pluripotency of embryonic stem cells (English)

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Angie Rizzino

1

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language of work or name

English

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publication date

2009

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Wiley interdisciplinary reviews. Systems biology and medicine

published in

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The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer

volume

1

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issue

2

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page(s)

228-36

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cites work

1 reference

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SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis

7 April 2017

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Core transcriptional regulatory circuitry in human embryonic stem cells

7 April 2017

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Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers

7 April 2017

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Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4

7 April 2017

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Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex

7 April 2017

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Induced pluripotent stem cell lines derived from human somatic cells

7 April 2017

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

7 April 2017

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Nanog and transcriptional networks in embryonic stem cell pluripotency

7 April 2017

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A protein interaction network for pluripotency of embryonic stem cells

7 April 2017

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Control of developmental regulators by Polycomb in human embryonic stem cells

7 April 2017

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Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells

7 April 2017

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Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling

7 April 2017

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Multipotent cell lineages in early mouse development depend on SOX2 function

7 April 2017

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Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4

7 April 2017

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Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3

7 April 2017

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New type of POU domain in germ line-specific protein Oct-4

7 April 2017

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The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

7 April 2017

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Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation

7 April 2017

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Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells

7 April 2017

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Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity

7 April 2017

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Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

7 April 2017

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Integration of external signaling pathways with the core transcriptional network in embryonic stem cells

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794141

Polycomb complexes repress developmental regulators in murine embryonic stem cells

7 April 2017

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Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

7 April 2017

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Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming

7 April 2017

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Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts

7 April 2017

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Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression

7 April 2017

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Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors

28 September 2017

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Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts

28 September 2017

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Identification of DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794141

Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794141

Differential regulation of the Oct-3/4 gene in cell culture model systems that parallel different stages of mammalian development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794141

Back to basics: Sox genes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794141

Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794141

Elevating the levels of Sox2 in embryonal carcinoma cells and embryonic stem cells inhibits the expression of Sox2:Oct-3/4 target genes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794141

Differential activity of the FGF-4 enhancer in F9 and P19 embryonal carcinoma cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794141

Regulatory networks in embryo-derived pluripotent stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794141

Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794141

Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794141

Identification of Sox-2 regulatory region which is under the control of Oct-3/4-Sox-2 complex

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794141

Molecular mechanism to maintain stem cell renewal of ES cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794141

Modulation of the activity of multiple transcriptional activation domains by the DNA binding domains mediates the synergistic action of Sox2 and Oct-3 on the fibroblast growth factor-4 enhancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794141

Expression of the K-fgf proto-oncogene is controlled by 3' regulatory elements which are specific for embryonal carcinoma cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794141

Identification of the transactivation domain of the transcription factor Sox-2 and an associated co-activator.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794141

Transcriptional regulation of the murine k-FGF gene in embryonic cell lines

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794141

Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis.

30 May 2018

1 reference

Human ES cell profiling broadens the reach of bivalent domains

21 January 2018

1 reference

Distinct regulatory elements govern Fgf4 gene expression in the mouse blastocyst, myotomes, and developing limb.

21 January 2018

1 reference

A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal

21 January 2018

1 reference

The co-activator p300 associates physically with and can mediate the action of the distal enhancer of the FGF-4 gene

21 January 2018

1 reference

12 December 2020

Transcription factor Sox-2 inhibits co-activator stimulated transcription

1 reference

12 December 2020

RNA polymerase II: just stopping by

1 reference

12 December 2020

Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells

1 reference

12 December 2020

Identifiers

DOI

10.1002/WSBM.12

1 reference

609307

609307

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