Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential (Q24658099)

Europe PubMed Central

title

Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential (English)

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author name string

Kate Petersen Shay

1

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Régis F Moreau

2

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Eric J Smith

3

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Anthony R Smith

4

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Tory M Hagen

Biochimica et Biophysica Acta

5

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language of work or name

English

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publication date

October 2009

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published in

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volume

1790

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issue

10

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page(s)

1149-60

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cites work

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Alpha-lipoic acid as a directly binding activator of the insulin receptor: protection from hepatocyte apoptosis

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Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

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Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.

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28 September 2017

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Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes

28 September 2017

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28 September 2017

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Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease

28 September 2017

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Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway

28 September 2017

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Differential redox regulation within the PTP superfamily

28 September 2017

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Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial.

28 September 2017

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Alpha-lipoic acid suppresses the development of collagen-induced arthritis and protects against bone destruction in mice

28 September 2017

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Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck).

28 September 2017

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Contraction signaling to glucose transport in skeletal muscle

28 September 2017

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Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

28 September 2017

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Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation

28 September 2017

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Prooxidant activities of alpha-lipoic acid on oxidative protein damage in the aging rat heart muscle

28 September 2017

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Effect of alpha-lipoic acid supplementation on markers of protein oxidation in post-mitotic tissues of ageing rat.

28 September 2017

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alpha-Lipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma

28 September 2017

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Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress

28 September 2017

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Lipoic acid is 10 times more toxic in cats than reported in humans, dogs or rats

28 September 2017

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Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

28 September 2017

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Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis

28 September 2017

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Alpha-lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis.

28 September 2017

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(R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis

28 September 2017

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Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid

28 September 2017

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α-Lipoic Acid and Cardiovascular Disease

28 September 2017

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Plasma Kinetics, Metabolism, and Urinary Excretion of Alpha‐Lipoic Acid following Oral Administration in Healthy Volunteers

28 September 2017

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Lipoic acid: a multifunctional antioxidant

28 September 2017

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Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.

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Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells

28 September 2017

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Molecular aspects of lipoic acid in the prevention of diabetes complications

28 September 2017

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Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

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Assay of protein-bound lipoic acid in tissues by a new enzymatic method

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28 September 2017

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Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway

28 September 2017

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Scavenging of hypochlorous acid by lipoic acid

28 September 2017

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Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo

28 September 2017

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Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-fat fed rats.

28 September 2017

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Biological assays and genomic analysis reveal lipoic acid modulation of endothelial cell behavior and gene expression

30 May 2018

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Dietary lipoic acid supplementation attenuates hypertension in Dahl salt sensitive rats

30 May 2018

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Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex

30 May 2018

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Alpha-lipoic acid decreases thiol reactivity of the insulin receptor and protein tyrosine phosphatase 1B in 3T3-L1 adipocytes

30 May 2018

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Insulin receptor substrate-1 and phosphoinositide-dependent kinase-1 are required for insulin-stimulated production of nitric oxide in endothelial cells

30 May 2018

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Prevention of hypertension, insulin resistance, and oxidative stress by alpha-lipoic acid

30 May 2018

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R-alpha-lipoic acid action on cell redox status, the insulin receptor, and glucose uptake in 3T3-L1 adipocytes

30 May 2018

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The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation.

30 May 2018

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Homocysteine and alpha-lipoic acid regulate p44/42 MAP kinase phosphorylation in NIH/3T3 cells

30 May 2018

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Differential regulation of MAP kinase signaling by pro- and antioxidant biothiols.

30 May 2018

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Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes

30 May 2018

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Fas mediated apoptosis of human Jurkat T-cells: intracellular events and potentiation by redox-active alpha-lipoic acid

30 May 2018

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Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants

30 May 2018

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Effects of treatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. A 4-month randomized controlled multicenter trial (DEKAN Study). Deutsche Kardiale Autonome Neuropathie

30 May 2018

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Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells

30 May 2018

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Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid.

30 May 2018

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The metabolism of dl-[1, 6-14C]lipoic acid in the rat

30 May 2018

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Thioctic Acid and Dihydrolipoic Acid are Novel Antioxidants Which Interact With Reactive Oxygen Species

30 May 2018

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Dihydrolipoic acid--a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals

30 May 2018

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Distribution study of orally administered lipoic acid in rat brain tissues

30 May 2018

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Pharmacokinetics of different formulations of tioctic (alpha-lipoic) acid in healthy volunteers

28 November 2018

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Comparative crossover, randomized, open-label bioequivalence study on the bioequivalence of two formulations of thioctic acid in healthy volunteers

28 November 2018

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Postmitotic tissue selenium and manganese levels in alpha-lipoic acid-supplemented aged rats

28 November 2018

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Oxidative inhibition of protein phosphatase 2A activity: role of catalytic subunit disulfides

28 November 2018

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Lipoic acid stimulates cAMP production in T lymphocytes and NK cells

28 November 2018

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Presynaptic mechanisms underlying the alpha-lipoic acid facilitation of glutamate exocytosis in rat cerebral cortex nerve terminals

28 November 2018

1 reference

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Safety evaluation of alpha-lipoic acid (ALA).

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Long-term safety of alpha-lipoic acid (ALA) consumption: A 2-year study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Lipoic acid inhibits expression of ICAM-1 and VCAM-1 by CNS endothelial cells and T cell migration into the spinal cord in experimental autoimmune encephalomyelitis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Lipoic acid supplementation prevents cyclosporine-induced hypertension and nephrotoxicity in spontaneously hypertensive rats.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Plasma protein oxidation in aging rats after alpha-lipoic acid administration

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Lipoic acid in multiple sclerosis: a pilot study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Pharmacokinetics of alpha-lipoic acid in subjects with severe kidney damage and end-stage renal disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Interactions of exercise training and alpha-lipoic acid on insulin signaling in skeletal muscle of obese Zucker rats

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Development of a sustained release dosage form for alpha-lipoic acid. II. Evaluation in human volunteers

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Salt-induced hypertension in WKY rats: prevention by alpha-lipoic acid supplementation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Lipoic acid prevents hypertension, hyperglycemia, and the increase in heart mitochondrial superoxide production

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Alpha lipoic acid changes iron uptake and storage in lens epithelial cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Effect of DL-alpha-lipoic acid on the status of lipid peroxidation and antioxidant enzymes in various brain regions of aged rats

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Peroxynitrite reaction with the reduced and the oxidized forms of lipoic acid: new insights into the reaction of peroxynitrite with thiols

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Effects of alpha-lipoic acid on deoxycorticosterone acetate-salt-induced hypertension in rats

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Protective role of DL-alpha-lipoic acid against mercury-induced neural lipid peroxidation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes--reversal with (R)-alpha-lipoic acid supplementation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Thiol chelation of Cu2+ by dihydrolipoic acid prevents human low density lipoprotein peroxidation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

alpha-Lipoic acid dependent regeneration of ascorbic acid from dehydroascorbic acid in rat liver mitochondria.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Neuroprotective effects of alpha-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

The antioxidant alpha-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Efficacy of hypochlorous acid scavengers in the prevention of protein carbonyl formation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Antioxidant activities of dihydrolipoic acid and its structural homologues

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

The potent free radical scavenger alpha-lipoic acid improves memory in aged mice: putative relationship to NMDA receptor deficits.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756298

(R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo

28 November 2018

1 reference

12 December 2020

Modelling cortical cataractogenesis XX. In vitro effect of alpha-lipoic acid on glutathione concentrations in lens in model diabetic cataractogenesis

1 reference

12 December 2020

Alpha-lipoic acid reduces expression of vascular cell adhesion molecule-1 and endothelial adhesion of human monocytes after stimulation with advanced glycation end products

1 reference

12 December 2020

Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation

1 reference

12 December 2020

Singlet oxygen induced single-strand breaks in plasmid pBR322 DNA: the enhancing effect of thiols

1 reference

12 December 2020

Prevention of singlet oxygen-induced DNA damage by lipoate

1 reference

12 December 2020

Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance

1 reference

12 December 2020

Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant?

1 reference

12 December 2020

Reduction of lipoic acid by lipoamide dehydrogenase

1 reference

12 December 2020

Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers

1 reference

12 December 2020

alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria

1 reference

12 December 2020

Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy

1 reference

12 December 2020

alpha-Ketoglutaric dehydrogenase. 8. Isolation and some properties of a flavoprotein compnent

1 reference

12 December 2020

alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats

1 reference

12 December 2020

Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy

1 reference

12 December 2020

Dietary alpha-lipoic acid supplementation lowers blood pressure in spontaneously hypertensive rats

1 reference

12 December 2020

Stimulation by alpha-lipoic acid of glucose transport activity in skeletal muscle of lean and obese Zucker rats

1 reference

12 December 2020

A method for measuring nitric oxide radical scavenging activity. Scavenging properties of sulfur-containing compounds

1 reference

12 December 2020

Transepithelial transport of alpha-lipoic acid across human intestinal Caco-2 cell monolayers

1 reference

12 December 2020

Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2

1 reference

12 December 2020

Alpha-lipoic acid inhibits matrix metalloproteinase-9 expression by inhibiting NF-kappaB transcriptional activity

1 reference

12 December 2020

Dietary lipoic acid supplementation prevents fructose-induced hypertension in rats

1 reference

12 December 2020

Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study)

1 reference

12 December 2020