Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins (Q24658387)

6

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Damian C Crowther

5

object named as

Damian C Crowther

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author name string

Heike Kroeger

1

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Ian MacLeod

3

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Juan Pérez

4

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David A Lomas

Journal of Biological Chemistry

7

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language of work or name

English

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publication date

21 August 2009

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published in

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volume

284

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issue

34

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page(s)

22793-802

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cites work

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Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy

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Structure of a serpin-protease complex shows inhibition by deformation

7 April 2017

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Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

7 April 2017

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Signal integration in the endoplasmic reticulum unfolded protein response

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ADD66, a gene involved in the endoplasmic reticulum-associated degradation of alpha-1-antitrypsin-Z in yeast, facilitates proteasome activity and assembly.

7 April 2017

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ERAD: the long road to destruction

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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

7 April 2017

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Mutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulum

7 April 2017

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Familial dementia caused by polymerization of mutant neuroserpin

7 April 2017

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CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

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7 April 2017

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Autophagy is activated for cell survival after endoplasmic reticulum stress

7 April 2017

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3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

7 April 2017

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Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

7 April 2017

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Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response.

7 April 2017

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Polymers and inflammation: disease mechanisms of the serpinopathies

28 September 2017

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Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans

28 September 2017

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The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB.

28 September 2017

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Sequestration of mutated alpha1-antitrypsin into inclusion bodies is a cell-protective mechanism to maintain endoplasmic reticulum function.

28 September 2017

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Aging perturbs 26S proteasome assembly in Drosophila melanogaster

28 September 2017

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Endoplasmic reticulum stress signaling in disease

28 September 2017

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Endoplasmic reticulum stress triggers autophagy

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755687

Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755687

Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755687

A conditional tissue-specific transgene expression system using inducible GAL4.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755687

The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755687

Neuroserpin mutation S52R causes neuroserpin accumulation in neurons and is associated with progressive myoclonus epilepsy

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755687

Signal transduction from the endoplasmic reticulum to the cell nucleus

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755687

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755687

Selective protein degradation in the yeast exocytic pathway

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755687

Accumulation of the insoluble PiZ variant of human alpha 1-antitrypsin within the hepatic endoplasmic reticulum does not elevate the steady-state level of grp78/BiP.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755687

A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755687

Endoplasmic reticulum stress: a new pathway to induce autophagy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755687

Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755687

Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19549782

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Retention of mutant alpha(1)-antitrypsin Z in endoplasmic reticulum is associated with an autophagic response

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19549782

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Degradation of a mutant secretory protein, alpha1-antitrypsin Z, in the endoplasmic reticulum requires proteasome activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19549782

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M109.027102

1 reference

3660885

3660885

1 reference

1 reference

1 reference