HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination (Q24670026)

1

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Mint Sirisawad

2

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Jun Chen

3

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Patti Thiemann

4

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Joseph J Buggy

Proceedings of the National Academy of Sciences of the United States of America

6

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language of work or name

English

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publication date

4 December 2007

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published in

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volume

104

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issue

49

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page(s)

19482-7

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cites work

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Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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Clinical development of histone deacetylase inhibitors as anticancer agents

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

7 April 2017

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p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y

7 April 2017

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Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray

7 April 2017

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DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma

7 April 2017

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Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance

7 April 2017

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In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation

7 April 2017

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

7 April 2017

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Anticancer activities of histone deacetylase inhibitors

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Poly(ADP-ribose): novel functions for an old molecule

7 April 2017

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Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

7 April 2017

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Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer

7 April 2017

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Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci

28 September 2017

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Radiosensitization of colorectal carcinoma cell lines by histone deacetylase inhibition

28 September 2017

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Histone deacetylation as a target for radiosensitization

28 September 2017

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Histone deacetylase inhibitors enhance phosphorylation of histone H2AX after ionizing radiation

28 September 2017

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CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo

28 September 2017

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Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

28 September 2017

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Modulation of cellular radiation responses by histone deacetylase inhibitors

28 September 2017

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Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapy

28 September 2017

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Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks

28 September 2017

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Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity

28 September 2017

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Analysis of ionizing radiation-induced foci of DNA damage repair proteins

28 September 2017

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Modulation of radiation response by histone deacetylase inhibition

28 September 2017

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Novel HDAC inhibitors with radiosensitizing properties

28 September 2017

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DNA repair, genome stability, and aging

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Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells

28 September 2017

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Histone deacetylase inhibitors FK228, N-(2-aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)amino- methyl]benzamide and m-carboxycinnamic acid bis-hydroxamide augment radiation-induced cell death in gastrointestinal adenocarcinoma cells

28 September 2017

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Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells

28 September 2017

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Elevated levels of Rad51 recombination protein in tumor cells.

28 September 2017

1 reference

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Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.

28 September 2017

1 reference

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Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage

28 September 2017

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Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks

28 September 2017

1 reference

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Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid

28 September 2017

1 reference

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Enhanced radiation-induced cell killing and prolongation of gammaH2AX foci expression by the histone deacetylase inhibitor MS-275.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0707828104

A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0707828104

Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.

21 January 2018

1 reference

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Homologous recombination is a highly conserved determinant of the synergistic cytotoxicity between cisplatin and DNA topoisomerase I poisons

21 January 2018

1 reference

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Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18042714

12 December 2020

inferred from PubMed ID database lookup

Measuring recombination proficiency in mouse embryonic stem cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18042714

12 December 2020

inferred from PubMed ID database lookup

Genetic control of diploid recovery after gamma-irradiation in the yeast Saccharomyces cerevisiae

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18042714

12 December 2020

inferred from PubMed ID database lookup

Chlorpropamide inhibition of excision repair and postreplication repair of ultraviolet damage in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0707828104

7 January 2021

inferred from DOI database lookup

Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0707828104

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1073/PNAS.0707828104

1 reference

ADS bibcode

2007PNAS..10419482A

0 references

1 reference

1 reference

PubMed publication ID

18042714

1 reference