PLZF is a negative regulator of retinoic acid receptor transcriptional activity (Q24672695)

2

object named as

Marie-Hélène Delmotte

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Perrine J Martin

object named as

Perrine J Martin

1

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author name string

Marie-Hélène Delmotte

2

0 references

Philippe Lefebvre

https://scigraph.springernature.com/pub.10.1186/1478-1336-1-6

4

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language of work or name

English

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publication date

6 September 2003

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1 reference

1

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issue

1

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page(s)

6

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exact match

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cites work

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The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase

7 April 2017

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Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling

7 April 2017

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Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies

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Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia

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PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors

7 April 2017

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Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains

7 April 2017

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Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid

7 April 2017

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The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor

7 April 2017

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Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

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Molecular basis for designing selective modulators of retinoic acid receptor transcriptional activities

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Serine 157, a retinoic acid receptor alpha residue phosphorylated by protein kinase C in vitro, is involved in RXR.RARalpha heterodimerization and transcriptional activity

28 September 2017

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Allosteric regulation of the discriminative responsiveness of retinoic acid receptor to natural and synthetic ligands by retinoid X receptor and DNA.

28 September 2017

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Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient

28 September 2017

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Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

28 September 2017

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The promyelocytic leukemia zinc finger protein affects myeloid cell growth, differentiation, and apoptosis

28 September 2017

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Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein

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H11-H12 loop retinoic acid receptor mutants exhibit distinct trans-activating and trans-repressing activities in the presence of natural or synthetic retinoids.

28 September 2017

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Sequence-specific DNA binding and transcriptional regulation by the promyelocytic leukemia zinc finger protein.

30 May 2018

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Control of retinoic acid receptor heterodimerization by ligand-induced structural transitions. A novel mechanism of action for retinoid antagonists.

30 May 2018

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The RAR alpha-PLZF chimera associated with Acute Promyelocytic Leukemia has retained a sequence-specific DNA-binding domain.

28 November 2018

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Reduced and altered DNA-binding and transcriptional properties of the PLZF-retinoic acid receptor-alpha chimera generated in t(11;17)-associated acute promyelocytic leukemia.

28 November 2018

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Thyroid hormone-mediated enhancement of heterodimer formation between thyroid hormone receptor beta and retinoid X receptor

28 November 2018

1 reference

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Overexpression, purification, characterization, and crystallization of the BTB/POZ domain from the PLZF oncoprotein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/14521715

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Poor response to all-trans retinoic acid therapy in a t(11;17) PLZF/RAR alpha patient

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/14521715