The antipsychotic drug chlorpromazine inhibits HERG potassium channels (Q24672703)

1

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Kezhong Wu

2

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Sven Kathöfer

3

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Wolfgang Schoels

5

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Johann Kiehn

6

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Christoph A Karle

British Journal of Pharmacology

7

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language of work or name

English

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publication date

June 2003

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published in

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volume

139

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issue

3

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page(s)

567-74

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cites work

The inward rectification mechanism of the HERG cardiac potassium channel

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A family of potassium channel genes related to eag in Drosophila and mammals

7 April 2017

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A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

7 April 2017

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Amiodarone: clinical trials

7 April 2017

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Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels

7 April 2017

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Bertosamil blocks HERG potassium channels in their open and inactivated states

7 April 2017

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Antipsychotic-related QTc prolongation, torsade de pointes and sudden death

28 September 2017

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Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death

28 September 2017

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Torsades de pointes associated with chlorpromazine: case report and review of associated ventricular arrhythmias.

28 September 2017

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High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872.

28 September 2017

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Antiarrhythmic drug carvedilol inhibits HERG potassium channels

28 September 2017

1 reference

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Novel characteristics of a misprocessed mutant HERG channel linked to hereditary long QT syndrome.

28 September 2017

1 reference

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Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

28 September 2017

1 reference

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Long QT syndromes and torsade de pointes

28 September 2017

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Torsade de pointes. Mechanisms and management.

28 September 2017

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Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline

28 September 2017

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Molecular determinants of dofetilide block of HERG K+ channels

30 May 2018

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The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes

30 May 2018

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Chlorpromazine activates chloride currents in Xenopus oocytes

30 May 2018

1 reference

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Molecular physiology and pharmacology of HERG. Single-channel currents and block by dofetilide

30 May 2018

1 reference

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Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573882

The antidepressant drug fluoxetine is an inhibitor of human ether-a-go-go-related gene (HERG) potassium channels

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573882

Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573882

Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573882

QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients

28 November 2018

1 reference

12 December 2020

The heart of psychotropic drug therapy

1 reference

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Chlorpromazine accumulation and sudden death in a patient with renal insufficiency

1 reference

12 December 2020

Plasma concentrations of antipsychotic drugs in psychiatric inpatients

1 reference

12 December 2020

Thioridazine lengthens repolarization of cardiac ventricular myocytes by blocking the delayed rectifier potassium current

1 reference

12 December 2020

Chlorpromazine-induced inhibition of catecholamine secretion by a differential blockade of nicotinic receptors and L-type Ca2+ channels in rat pheochromocytoma cells

1 reference

12 December 2020