Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease (Q24673502)

1

0 references

Sarah E Gale

2

0 references

Andrey Frolov

3

0 references

Ikuko Mohri

4

0 references

Kinuko Suzuki

5

0 references

Synthia H Mellon

6

0 references

Steven U Walkley

7

0 references

Jean E Schaffer

9

0 references

Daniel S Ory

Proceedings of the National Academy of Sciences of the United States of America

10

0 references

language of work or name

English

0 references

publication date

12 September 2006

0 references

published in

0 references

volume

103

0 references

issue

37

0 references

page(s)

13807-12

0 references

cites work

Cell-autonomous death of cerebellar purkinje neurons with autophagy in Niemann-Pick type C disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564205

NPC1 and NPC2 Regulate Cellular Cholesterol Homeostasis through Generation of Low Density Lipoprotein Cholesterol-derived Oxysterols

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564205

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564205

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564205

PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564205

Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564205

An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564205

Neonatal phenobarbital imprints overexpression of cytochromes P450 with associated increase in tumorigenesis and reduced life span

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564205

Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late endosomes/lysosomes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564205

Correction: Uncoupling of Longevity and Telomere Length in C. elegans

7 April 2017

1 reference

https://api.crossref.org/works/10.1073/PNAS.0606218103

Allopregnanolone treatment, both as a single injection or repetitively, delays demyelination and enhances survival of Niemann-Pick C mice.

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564205

Consequences of NPC1 and NPC2 loss of function in mammalian neurons

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564205

The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564205

A defect in cholesterol esterification in Niemann-Pick disease (type C) patients

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564205

Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564205

Murine Model of Niemann-Pick C Disease: Mutation in a Cholesterol Homeostasis Gene

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564205

Enantioselectivity of steroid-induced gamma-aminobutyric acidA receptor modulation and anesthesia.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564205

The transport of low density lipoprotein-derived cholesterol to the plasma membrane is defective in NPC1 cells

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606218103

Impaired ABCA1-dependent lipid efflux and hypoalphalipoproteinemia in human Niemann-Pick type C disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606218103

Cerebellar degeneration in the Niemann-Pick type C mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606218103

Apoptosis accompanied by up-regulation of TNF-alpha death pathway genes in the brain of Niemann-Pick type C disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606218103

Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606218103

27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606218103

Regulation of Cholesterol Homeostasis by the Liver X Receptors in the Central Nervous System

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606218103

Predominantly neuronal expression of cytochrome P450 isoforms CYP3A11 and CYP3A13 in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606218103

CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606218103

Cholesterol and oxygenated cholesterol concentrations are markedly elevated in peripheral tissue but not in brain from mice with the Niemann-Pick type C phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606218103

The sterol-sensing domain of the Niemann-Pick C1 (NPC1) protein regulates trafficking of low density lipoprotein cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606218103

Mutation in saposin D domain of sphingolipid activator protein gene causes urinary system defects and cerebellar Purkinje cell degeneration with accumulation of hydroxy fatty acid-containing ceramide in mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606218103

A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564205

Low density lipoprotein (LDL)-mediated suppression of cholesterol synthesis and LDL uptake is defective in Niemann-Pick type C fibroblasts

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16940355

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Intracellular trafficking of cholesterol monitored with a cyclodextrin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16940355

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0606218103

1 reference

ADS bibcode

2006PNAS..10313807L

0 references

1 reference

1 reference

PubMed publication ID

16940355

1 reference