Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL (Q24675588)

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Hidehiko Kawai

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JiJie Gu

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Zhi-Min Yuan

Molecular and Cellular Biology

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language of work or name

English

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publication date

June 2003

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published in

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volume

23

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issue

12

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page(s)

4230-46

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cites work

MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function

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The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis

7 April 2017

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Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice

7 April 2017

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p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

7 April 2017

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Binding and modulation of p53 by p300/CBP coactivators

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Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors

7 April 2017

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An RNA polymerase II elongation factor encoded by the human ELL gene

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Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia

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p53, the cellular gatekeeper for growth and division

7 April 2017

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Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53

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p53 mutations in human cancers

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Identification of p53 sequence elements that are required for MDM2-mediated nuclear export

7 April 2017

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Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

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Malignancy: Tumor Suppressor Gene Aberrations in Acute Myelogenous Leukemia

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Human homologue of yeast Rad23 protein A interacts with p300/cyclic AMP-responsive element binding (CREB)-binding protein to down-regulate transcriptional activity of p53.

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Identification of a sequence element from p53 that signals for Mdm2-targeted degradation

28 September 2017

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Transcriptional inhibition of p53 by the MLL/MEN chimeric protein found in myeloid leukemia.

28 September 2017

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Mechanisms of p53-mediated apoptosis

28 September 2017

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Novel receptor interaction and repression domains in the orphan receptor SHP.

28 September 2017

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Subcellular localization of the MEN, MLL/MEN and truncated MLL proteins expressed in leukemic cells carrying the t(11;19)(q23;p13.1) translocation

28 September 2017

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The HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures

28 September 2017

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A transactivation-deficient mouse model provides insights into Trp53 regulation and function

28 September 2017

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Overexpression of the MEN/ELL protein, an RNA polymerase II elongation factor, results in transformation of Rat1 cells with dependence on the lysine-rich region

30 May 2018

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A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL.

30 May 2018

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Identification of novel polymorphisms in intron 7 of the human p53 gene in acute myeloid leukemia and healthy donors

28 November 2018

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12 December 2020

Detection of p53 gene mutations by single strand conformational polymorphism (SSCP) in human acute myeloid leukemia-derived cell lines

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12 December 2020

The translocations, t(11;19)(q23;p13.1) and t(11;19)(q23;p13.3): a cytogenetic and clinical profile of 53 patients. European 11q23 Workshop participants

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12 December 2020

An integral membrane green fluorescent protein marker, Us9-GFP, is quantitatively retained in cells during propidium iodide-based cell cycle analysis by flow cytometry

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12 December 2020

Loss of heterozygosity in childhood de novo acute myelogenous leukemia

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12 December 2020

Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression

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12 December 2020

10.1128/MCB.23.12.4230-4246.2003

Identifiers

DOI

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PubMed publication ID

12773566

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